Apoptosis

Apoptosis is an evolutionarily conserved process for the elimination of redundant, damaged, or dangerous cells. Two main pathways of apoptosis are extrinsic and intrinsic as well as the perforin/granzyme pathway. The intrinsic pathway is activated by cellular stress and governed by Bcl-2 family. The extrinsic pathway is stimulated by death receptor ligation. Another perforin/granzyme pathway is initiated by cytotoxic granules released by CTLs (cytotoxic T-cells) and NK (natural killer) cells. Each pathway triggers the activation of caspase cascade and the following proteolysis of various proteins. arigo offers quality antibodies to facilitate apoptosis research.

- Product highlight -

- Apoptosis marker-

Caspase-3 (cleaved) antibody (ARG57512)

PARP (cleaved) antibody (ARG20041)

- Bax/Bcl-2 ratio -

- Cytotoxicity -

Granzyme B ELISA Kit (ARG80171)
Sensitivity: 30 pg/ml
Sample: Serum, plasma, cell culture sup.

Perforin ELISA Kit (ARG80173)
Sensitivity: 20 pg/ml
Sample: Serum, plasma, cell culture sup.

- Bcl-2 family -

Bcl-2 family proteins act as a gatekeeper to the intrinsic apoptosis. The members either inhibit or promote apoptosis, and regulate mitochondrial outer membrane permeabilization.

- MOMP -

- Caspase cascade -

- Granzyme & Perforin -

Read more
Programmed cell death 
Necroptosis
Pyroptosis
Ferroptosis
Autophagy

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Flyer of Bcl-2 Family
Poster of Cell death