Epithelial-Mesenchymal Transition (EMT)

Epithelial-mesenchymal transition (EMT) is a process by which polarized epithelial cells are transformed into mesenchymal cells and show reduced cell adhesion, increased motility and invasive properties. EMT is classified into 3 types: type 1 is associated with embryonic development of many tissues and organs, type 2 is associated with repair processes including wound healing, tissue regeneration, and organ fibrosis, and type 3 is associated with cancer progression and metastasis.

arigo offers excellent EMT marker antibodies for studying the transition and transcription regulation by transcription factors.

Loss of epithelial markers

Transcriptional shift

Gain of mesenchymal markers

E-Cadherin
Claudins
Cytokeratins

Desmoglein
Desmocollin
Occludin

Snail
Slug
Twist

ZEB1/2
FoxC2
LEF-1

Vimentin
N-Cadherin
Fibronectin

Vitronectin
α-SMA
S100A

Epithelial markers

E-Cadherin antibody (ARG55914)	ZO-1 antibody (ARG55738)

Cat. No.	Product	Clonality	Reactivity	Application
ARG65402	E-Cadherin antibody [67A4]	Mouse mAb	Hu	FACS, ICC/IF, IHC-Fr, IP, WB
ARG10954	Desmoglein 1 antibody [32-2B]	Mouse mAb	Hu, Bo	EM, IHC, ICC/IF, WB
ARG70009	Desmocollin antibody	Rabbit pAb	Hu	WB, IHC-P, FACS
ARG57245	JAM-A antibody [RM275]	Rabbit mAb	Hu	IHC-P, WB
ARG53386	Occludin antibody	Rabbit pAb	Hu, Ms	IHC-P, WB
ARG57552	ZO-1 antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB
ARG55738	ZO-1 antibody	Goat pAb	Hu, Ms, Rat, Dog, Mk	ICC/IF, WB

Mesenchymal markers

Vimentin antibody [SQab1859] (ARG66302)	Fibronectin antibody (ARG66162)	α-SMA antibody (ARG66246)

Cat. No.	Product	Clonality	Reactivity	Application
ARG66302	Vimentin antibody [SQab1859]	Mouse mAb	Hu, Ms, Rat, Ch, Dog, Gt, Hm, Mk, Pig, X, Zfsh	FACS, ICC/IF, IHC-P, IHC-Fr, WB
ARG57642	Vimentin antibody	Rabbit pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
ARG52468	Vimentin antibody	Chicken pAb	Hu, Ms, Rat, Bo	ICC/IF, WB
ARG22587	N-Cadherin antibody [13A9]	Mouse mAb	Hu, Rat	ICC/IF, IHC-P, IHC-Fr, IP, WB
ARG56127	Fibronectin antibody [FN12-8]	Mouse mAb	Hu, Bo	IHC-P, IHC-Fr, Inhib, WB
ARG52485	α-SMA antibody [1A4]	Mouse mAb	Hu, Ms, Rat, Pig, Rb, Sh	ELISA, ICC/IF, IHC-P, IHC-Fr, WB
ARG66246	α-SMA antibody [SQab1735]	Rabbit pAb	Hu, Ms, Rat	FACS, IHC-P, WB
ARG63621	α-SMA antibody	Goat pAb	Hu, Ms, Rat, Pig	ICC/IF, IHC-P, WB
ARG55904	S100A4 antibody	Mouse mAb	Hu	IP, WB
ARG55205	S100A4 antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB
ARG64101	S100A4 antibody	Goat pAb	Hu	IHC-P, WB
ARG54601	Vitronectin antibody [VN58-1]	Mouse mAb	Hu	ELISA, IHC

Transcription factors for EMT

Snail antibody (ARG64061)	Bmi-1 antibody (ARG55885)

Cat. No.	Product	Clonality	Reactivity	Application
ARG54986	Snail antibody	Mouse mAb	Hu	IHC-P, WB
ARG56427	Snail antibody	Rabbit pAb	Hu, Ms, Rat	IHC-P, WB
ARG64061	Snail antibody	Goat pAb	Hu, Ms	IHC, WB
ARG55242	Slug antibody	Rabbit pAb	Hu, Ms, Rat	ICC/IF, IHC-P, WB
ARG57524	ZEB1 antibody	Mouse mAb	Hu	FACS, IHC-P, WB
ARG64856	ZEB1 antibody	Goat pAb	Hu, Ms	WB
ARG55885	Bmi-1 antibody	Rabbit pAb	Hu, Ms	ICC/IF, WB
ARG63332	FOXC2 antibody	Goat pAb	Hu	IHC-P, WB
ARG64029	LEF1 antibody	Goat pAb	Hu, Ms, Rat	WB
ARG64126	TCF3 antibody	Goat pAb	Hu	IHC-P, WB