Senescence Marker Antibody Panel is launched

Senescence is a state of permanent cell cycle arrest. It can be induced by telomere shortening, DNA damages or other cellular stresses. Senescence has been implicated as a major cause of age-related diseases and believed to prevent cancer progression. arigo offers a series of antibodies and ELISA kits to facilitate the characterization of cellular senescence.

► Cell cycle arrest (SAGA)

Senescence Marker Antibody Panel (ARG30340)

● Includes antibodies for studying p16 ^INK4a-Rb pathway
● Includes antibodies for studying p53-p21 pathway
● Works on human samples

Component	Reactivity	Application
p16 ^INK4a antibody	Hu, Ms, Rat	ICC/IF, IP, WB
Rb pSer807 antibody	Hu, Ms, Rat	IHC-P, WB
p53 antibody [Pab1801]	Hu	ChIP, ELISA, FACS, ICC/IF, IHC-Fr, IHC-P, IP, WB
p21 antibody	Hu, Ms, Rat	ICC/IF, WB

► Senescence-associated Heterochromatin Foci (SAHF)

Heterochromatin Foci Antibody Duo (ARG30341)

● Includes H3K9me2 and HP1 gamma antibodies
● Outstanding ICC and IHC performance
● Works on human, mouse, and rat samples

► DNA damage & Loss of Lamin B1

gamma H2A.X antibody (ARG55251)

Reactivity: Hu, Ms
Application: ICC/IF, WB

Lamin B1 antibody (ARG65740)

Reactivity: Hu, Ms, Rat
Application: ICC/IF, IHC-P, WB

► SA-beta-Gal activity

Cellular Senescence Assay Kit (ARG82213)

● Ideal for quantification of senescence
● Efficiently detect SA-β-Gal activity from lysates
● Easy-to-use procedure with results within 1~3 hrs
● Compatible with all cell types

► Senescence-associated Secretory Phenotype (SASP)

ELISK kit	Human	Mouse	Rat
HMGB1	ARG81185	ARG81310	ARG81310
IL-1 alpha	ARG80191	ARG80204	ARG80237
IL-6	ARG80110	ARG80199	ARG80233
IL-8	ARG80111
CCL-2/MCP1	ARG80128	ARG80212	ARG80246
CXCL1	ARG81631	ARG80208	ARG80236
MMP-1	ARG80145	ARG82074	ARG82075
MMP-3	ARG83037	ARG81662	ARG82625