ARG30131

Postsynaptic Receptor Antibody Panel (NMDAR2A, NMDAR2B, GluR1)

Datasheet

Publication1

Ordering Information

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Price (USD)

1 kit

919.00

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Component

Cat No	Component Name	Host clonality	Reactivity	Application	Package
ARG52358	anti-NMDAR2A antibody	Rabbit pAb	Ms, Rat, Rb	IHC-Fr, WB	50 μl
ARG52363	anti-NMDAR2B antibody	Rabbit pAb	Ms, Rat	WB	50 μl
ARG52314	anti-GluR1 antibody [RH95]	Mouse mAb	Ms, Rat	WB	50 μl
ARG65350	Goat anti-Mouse IgG antibody (HRP)	Goat pAb	Ms	ELISA, IHC-P, WB	50 μl
ARG65351	Goat anti-Rabbit IgG antibody (HRP)	Goat pAb	Rb	ELISA, IHC-P, WB	50 μl

Overview

Product Description	Synaptic plasticity, the variable efﬁcacy of neurotransmission at synapses, is thought to form the memories. Glutaminergic synapses mediate virtually all excitatory neurotransmission in mammalian brains. Glutamate released from presynaptic terminals activates several types of glutamate-gated ion channels on postsynaptic membranes, including a-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA) receptors, consist of subunits GluR1-GluR4, and N-methyl-D-aspartate (NMDA) receptors. Changes in AMPA receptors at the postsynaptic membrane cause changes in synaptic strength, the best-characterized forms of which are long-term potentiation (LTP) and long-term depression (LTD). This antibody panel could be used to investigate the ratio of NMDAR to AMPAR or the change of AMPAR on the postsynaptic membrane. During the LTP, the AMPARs increase expression on the membrane of post-synapse, and the ratio of NMDAR to AMPAR would be higher than the pre-LTP. In construct, LTD decreases the AMPARs expression, and the ratio would be lower than pre-LTD.
Target Name	Postsynaptic Receptor
Alternate Names	Postsynaptic Receptor antibody; GluR1 antibody; NMDAR2A antibody; NMDAR2B antibody

Properties

Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Gene Full Name	Antibody Panel for Postsynaptic Receptor (NMDAR2A, NMDAR2B, GluR1)
Research Area	Immune System antibody; Neuroscience antibody

Images (4) Click the Picture to Zoom In

ARG52358 anti-NMDAR2A antibody WB image

Western Blot: 10 µg of Rat hippocampal (Hipp) lysate stained with ARG52358 anti-NMDAR2A antibody showing specific immunolabeling of the ~180 kDa NR2A subunit of the NMDA receptor.
ARG52314 anti-GluR1 antibody [RH95] WB image

Western Blot: rat hippocampal lysate showing specific immunolabeling of the ~105k GluR1 protein stained with GluR1 antibody (ARG52314).
ARG52363 anti-NMDAR2B antibody WB image

Western blot: 10 ug of rat hippocampal (Hipp) lysate stained with ARG52363 anti-NMDAR2B antibody showing specific immunolabeling of the ~180k NR2B subunit of the NMDA receptor.
ARG52358 anti-NMDAR2A antibody IHC-Fr image

Immunohistochemistry: Rabbit retina stained with ARG52358 anti-NMDAR2A antibody showing NR2A in the rod and cone photoreceptors in the outer plexiform layer as well as the entire inner plexiform layer.