ARG52314
anti-GluR1 antibody [RH95]
anti-GluR1 antibody [RH95] for Western blot and Mouse,Rat
Neuroscience antibody; Postsynaptic Receptor antibody
Overview
| Product Description | Mouse Monoclonal antibody [RH95] recognizes GluR1 |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | RH95 |
| Isotype | IgG2a |
| Target Name | GluR1 |
| Antigen Species | Rat |
| Immunogen | KLH-conjugated synthetic peptide around the N-terminal region of Rat GluR1. |
| Conjugation | Un-conjugated |
| Alternate Names | GLUH1; GluA1; GluR-1; Glutamate receptor ionotropic, AMPA 1; GluR-K1; GLUR1; HBGR1; AMPA-selective glutamate receptor 1; GluR-A; GLURA; Glutamate receptor 1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Specific for the ~105k GluR1 protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein G purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GRIA1 |
| Gene Full Name | glutamate receptor, ionotropic, AMPA 1 |
| Background | The ion channels activated by glutamate are typically divided into two classes. Those that are sensitive to N-methyl-D-aspartate (NMDA) are designated NMDA receptors (NMDAR) while those activated by α-amino-3-hydroxy-5-methyl-4-isoxalone propionic acid (AMPA) are known as AMPA receptors (AMPAR). The AMPAR are comprised of four distinct glutamate receptor subunits designated (GluR1-4) and they play key roles in virtually all excitatory neurotransmission in the brain (Keinänen et al., 1990;Hollmann and Heinemann, 1994). |
| Highlight | Related Antibody Duos and Panels: ARG30131 Postsynaptic Receptor Antibody Panel (NMDAR2A, NMDAR2B, GluR1) ARG30132 Phospho GluR1 Antibody Panel Related products: GluR1 antibodies; GluR1 Duos / Panels; Anti-Mouse IgG secondary antibodies; |
| Research Area | Neuroscience antibody; Postsynaptic Receptor antibody |
| Calculated MW | 102 kDa |
| PTM | Palmitoylated. Depalmitoylated upon glutamate stimulation. Cys-603 palmitoylation leads to Golgi retention and decreased cell surface expression. In contrast, Cys-829 palmitoylation does not affect cell surface expression but regulates stimulation-dependent endocytosis (By similarity). Phosphorylated at Ser-645. Phosphorylated at Ser-710 by PKC. Phosphorylated at Ser-849 by PKC, PKA and CAMK2. Phosphorylated at Ser-863 by PKC, PKA and PRKG2. |
Images (1) Click the Picture to Zoom In
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ARG52314 anti-GluR1 antibody [RH95] WB image
Western blot: Rat hippocampal lysate stained with ARG52314 anti-GluR1 antibody [RH95].
