Total solutions for HMGB1 research

HMGB1 is a multifunctional protein with various roles in different cellular compartments. It is associated with various pathogenesis such as cancers, neurodegenerative disorders, and multiple inflammatory diseases. HMGB1 has attracted the attention of both basic and clinical researchers as HMGB1 is a therapeutic target for a wide range of diseases. arigo offers a total solution to facilitate the HMGB1-related research.

Nuclear and cytosolic HMGB1
In the nucleus, HMGB1 acts as a DNA-binding protein for gene transcription, gene regulation and DNA repair. In the cytosol, HMGB1 induces autophagy by interacting with Beclin-1 which results in its dissociation from Bcl2 and the subsequent induction of autophagy.

Extracellular HMGB1
In the extracellular compartment, HMGB1 is passively released by necrotic cells and acts as a chemokine and DAMP (Damage-associated molecular pattern) to trigger inflammatory responses. Besides, HMGB1 is also secreted from activated dendritic cells and macrophages and functions as a cytokine, it acts as a ligand for RAGE, TLR-2 and TLR-4 thus activating the signal pathways and the following inflammation responses.

● Stimulation

HMGB1 protein (ARG70220)
● Active protein
● Low endotoxin
● Works on human and mouse cells

● Neutralization

HMGB1 Neutralizing antibody
[SQab20175] (ARG66714)
● Effective in vitro & in vivo neutralization
● Low endotoxin
● Works on human and mouse cells
● Good for ELISA, FACS, Neut, WB

● Detection

HMGB1 antibody [SQab1711] (ARG65863)
● Good for ELISA, FACS, ICC/IF, IHC-P, WB
● Works on human, mouse, and rat samples

● Quantification

The most comprehensive HMGB1 ELISA Kits

● HMGB1 specific. No cross reactivity with HMGB2.
● Suitable for multiple samples from multiple species.
● Easy & Fast procedures.

Human HMGB1 ELISA Kit (ARG81185)	Selected citations: Huang et al., (2024) Int Immunopharmacol. 127:111397. Yasuda et al., (2023) J Autoimmun. 142:103149. Hurtado-Navarro et al., (2023) Cell Rep Med. 4(12):101329. Jung et al., (2023) Biomaterials. 298:122127. Jung et al., (2022) Biomaterials. 287:121681. Li et al., (2022) J Exp Clin Cancer Res. 41(1):74.
Mouse/Rat HMGB1 ELISA Kit (ARG81310)	Citations: Wang et al. (2021) Nano Today. 37:101064. Wang et al., (2021) ACS Nano. 15(3):5405-5419. Fukushima et al., (2021) Int J Mol Sci. 22(2):535. Liu et al., (2021) Mol Med. 27(1):11. Yang et al., (2021) Front Microbiol. 12:682255. Hiramoto et al., (2021) J Clin Biochem Nutr. 69(1):52-60. Chen et al., (2020) Nano Today. 35:100924. Wang et al., (2020) Oncogenesis. 9(9):82. Kim et al., (2020) Vaccines (Basel). 8(4):699. Song et al., (2019) Nat Commun. 10(1):3745.
Serum HMGB1 ELISA Kit (ARG81351)	Citations: Zhao et al., (2021) Front Pharmacol. 12:701087. Chen et al., (2021) Sci Rep. 11(1):5059. Bai et al., (2021) Exp Ther Med. 22(1):679. Ahn et al., (2021) In Vivo. 35(3):1761-1768. Wen et al., (2020) FASEB 34(3):4384-4402. Wei et al., (2020) Neuroscience. 437:23-33. Matsumoto et al., (2020) Pancreas. 49(4):503-508. Akasaka et al., (2019) Int J Mol Sci. 20(21):5462