ARG30214
Phospho STAT5A Antibody Duo (Total, pY694)
Gene Regulation antibody; Signaling Transduction antibody
Publication2
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51552 | anti-STAT5A phospho (Tyr694) antibody | Rabbit pAb | Hu, Ms, Rat | IHC-P, WB | 50 μl |
| ARG65593 | anti-STAT5A antibody | Rabbit pAb | Hu | IHC-P, WB | 50 μl |
Overview
| Product Description | STAT5A belongs to STAT family of transcription factors which can be activated by various stimuli such as cytokines and growth factors, including IL-2, GM-CSF, Erythropoietin and Thrombopoietin. The phosphorylation of STAT5A at Tyr694 residue by SRS Kinase upon Erythropoietin stimulation triggers its activation and is responsible for EPO-induced signal transduction. STAT5A phosphorylation can also be induced by Prolactin to increase its DNA binding and transcription ability. Lin and Leonard. 2000. Oncogene 19(21):2566 Okutani et al. 2001. Oncogene 20(45):6643 Gouilleux et al. 1994. EMBO J 13(18):4361-9 |
|---|---|
| Target Name | STAT5A |
| Alternate Names | Phospho STAT5A antibody; Phospho Signal transducer and activator of transcription 5A antibody; STAT5A phospho (Tyr694) antibody; STAT5A antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho Signal transducer and activator of transcription 5A (STAT5A) Antibody Duo (Total, pY694) |
|---|---|
| Research Area | Gene Regulation antibody; Signaling Transduction antibody |
Images (4) Click the Picture to Zoom In
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ARG51552 anti-STAT5A phospho (Tyr694) antibody WB image
Western Blot: extracts from K562 cells untreated or treated with G-CSF stained with anti-STAT5A (phospho Tyr694) antibody ARG51552.
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ARG51552 anti-STAT5A phospho (Tyr694) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-STAT5A (phospho Tyr694) antibody ARG51552 (left) or the same antibody preincubated with blocking peptide (right).
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ARG65593 anti-STAT5A Antibody IHC-P image
Immunohistochemistry: paraffin-embedded Human breast carcinoma tissue stained with ARG65593 (STAT5A Antibody) at 1/50 dilution, or the same antibody preincubated with synthetic peptide (right). (Original magnification: ×200)
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ARG65593 anti-STAT5A Antibody WB image
Western Blot: ARG65593 STAT5A Antibody at 1/500 dilution with 30 μg of lysates.
(1) HeLa cell
(2) K562 cell
Exposure time: 1 minute.
Specific References
Effects of di (2-ethylhexyl) phthalate and high-fat diet on lipid metabolism in rats by JAK2/STAT5.
ARG51552: WB / Rat
Mono-2-ethylhexyl phthalate (MEHP) promoted lipid accumulation via JAK2/STAT5 and aggravated oxidative stress in BRL-3A cells.
ARG51552: WB / Rat
