Examining RSL3-induced activation of Keap1-Nrf2-ARE pathway

arigo is proud to announce that our Keap1-Nrf2-ARE antibody panel (ARG30345) was referenced by Kuo et al. for examining Nrf2/HO-1 activation induced by RSL3. This antibody panel comprises Nrf2 antibody as well as Nrf2 regulator Keap1 and antioxidant enzymes NQO1 and HO-1 antibodies. It is the best solution to facilitate the research of Keap1-Nrf2-ARE pathway.

 

 

 

 

Cellular effects of Nrf2
 

Nrf2 is a master regulator of antioxidant responses. It mediates cellular resistance to oxidants by regulating gene expression for eliminating ROS, promoting autophagy, inhibiting ferroptosis, and delaying senescence. NRF2 is emerging as an attractive therapeutic approach in diseases associated oxidative stress. arigo offers multiple antibody panels for investigating the roles of Nrf2 in various cellular responses.

 

Ferroptosis/Oxytosis Antibody Panel (ARG30337) ● GPX4          ● xCT ● 4-HNE

Senescence Marker Antibody Panel (ARG30340) ● p16       ● Rb pSer807 ● p53       ● p21

Autophagy Antibody Panel (ARG30321) ● LC3B        ● SQSTM1 ● Beclin-1