ARG67023
anti-UTRN / Utrophin antibody
anti-UTRN / Utrophin antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes UTRN / Utrophin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | UTRN / Utrophin |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to a region of Human UTRN / Utrophin. |
| Conjugation | Un-conjugated |
| Protein Full Name | Utrophin |
| Alternate Names | Utrophin; DRP1; DMDL; DRP; Dystrophin-Related Protein; Utrophin (Homologous To Dystrophin); DRP-1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | IHC-P: Antigen retrieval: boil tissue sections in 10 mM citrate buffer (pH 6.0) for 10-20 min and allow samples to cool to RT before staining. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS, 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | UTRN |
| Gene Full Name | utrophin |
| Background | This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008] |
| Function | May play a role in anchoring the cytoskeleton to the plasma membrane. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| Calculated MW | 395 kDa |
| PTM | Phosphoprotein; Showing features for chain, modified residue. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67023 anti-UTRN / Utrophin antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human tonsil tissue was stained with ARG67023 anti-UTRN / Utrophin antibody at 1:200 dilution. Antigen Retrieval: Boil tissue section in Tris-EDTA (pH 9.0) for 20 min.
