ARG43810
anti-UTRN / Utrophin antibody
anti-UTRN / Utrophin antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes UTRN / Utrophin |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | UTRN / Utrophin |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to a.a. L1211-K2294 of Human UTRN / Utrophin. |
| Conjugation | Un-conjugated |
| Protein Full Name | Utrophin |
| Alternate Names | Utrophin; DRP1; DMDL; DRP; Dystrophin-Related Protein; Utrophin (Homologous To Dystrophin); DRP-1 |
Application Instructions
| Application Suggestion |
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| Application Note | IHC-P: Antigen retrieval: boil tissue sections in 1mM EDTA (pH 9.0) for 20 min and allow samples to cool to RT before staining. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | UTRN |
| Gene Full Name | utrophin |
| Background | This gene shares both structural and functional similarities with the dystrophin gene. It contains an actin-binding N-terminus, a triple coiled-coil repeat central region, and a C-terminus that consists of protein-protein interaction motifs which interact with dystroglycan protein components. The protein encoded by this gene is located at the neuromuscular synapse and myotendinous junctions, where it participates in post-synaptic membrane maintenance and acetylcholine receptor clustering. Mouse studies suggest that this gene may serve as a functional substitute for the dystrophin gene and therefore, may serve as a potential therapeutic alternative to muscular dystrophy which is caused by mutations in the dystrophin gene. Alternative splicing of the utrophin gene has been described; however, the full-length nature of these variants has not yet been determined. [provided by RefSeq, Jul 2008] |
| Function | May play a role in anchoring the cytoskeleton to the plasma membrane. [UniProt] |
| Cellular Localization | Cell membrane; Cytoplasm; Cytoskeleton; Membrane; Postsynaptic cell membrane; Synapse. [UniProt] |
| Calculated MW | 395 kDa |
| PTM | Phosphoprotein; Showing features for chain, modified residue. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG43810 anti-UTRN / Utrophin antibody ICC/IF image
Immunofluorescence: Caco2 cells were stained with ARG43810 anti-UTRN / Utrophin antibody antibody (green) at 1:100 dilution at 4°C for overnight. DAPI (blue) was used for nuclear staining.
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ARG43810 anti-UTRN / Utrophin antibody WB image
Western blot: 1) HeLa cell lysates, 2) human Sw620 whole cell lysates, 3) human Caco-2 whole cell lysates, 4) human THP-1 whole cell lysates, 5) mouse lung tissue lysates stained with ARG43810 anti-UTRN / Utrophin antibody.
