ARG41957
anti-SOX10 antibody
anti-SOX10 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes SOX10 |
|---|---|
| Tested Reactivity | Rat |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | SOX10 |
| Antigen Species | Human |
| Immunogen | An 18 amino acid peptide near the N-terminus of Human SOX10. |
| Conjugation | Un-conjugated |
| Alternate Names | WS4C; PCWH; DOM; Transcription factor SOX-10; WS2E; WS4 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Rat heart | ||||||
| Observed Size | ~ 54 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS and 0.02% Sodium azide. |
| Preservative | 0.02% Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | SOX10 |
| Gene Full Name | SRY (sex determining region Y)-box 10 |
| Background | SOX10 is a member of the SOX (SRY-related HMG-box) family of transcription factors involved in the regulation of embryonic development and in the determination of the cell fate. The encoded protein may act as a transcriptional activator after forming a protein complex with other proteins. This protein acts as a nucleocytoplasmic shuttle protein and is important for neural crest and peripheral nervous system development. Mutations in this gene are associated with Waardenburg-Shah and Waardenburg-Hirschsprung disease. [provided by RefSeq, Jul 2008] |
| Function | SOX10 is a transcription factor that plays a central role in developing and mature glia. Specifically activates expression of myelin genes, during oligodendrocyte (OL) maturation, such as DUSP15 and MYRF, thereby playing a central role in oligodendrocyte maturation and CNS myelination. Once induced, MYRF cooperates with SOX10 to implement the myelination program. Transcriptional activator of MITF, acting synergistically with PAX3 (PubMed:21965087). [UniProt] |
| Cellular Localization | Cytoplasm. Nucleus. Mitochondrion outer membrane; Peripheral membrane protein; Cytoplasmic side. [UniProt] |
| Calculated MW | 50 kDa |
Images (3) Click the Picture to Zoom In
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ARG41957 anti-SOX10 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Rat heart tissue stained with ARG41957 anti-SOX10 antibody at 5 µg/ml dilution.
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ARG41957 anti-SOX10 antibody WB image
Western blot: Rat heart lysates stained with ARG41957 anti-SOX10 antibody at 1 and 2 µg/ml dilution.
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ARG41957 anti-SOX10 antibody IHC image
Immunohistochemistry: Rat heart tissue stained with ARG41957 anti-SOX10 antibody at 20 µg/ml dilution.
