ARG43882
anti-Renin antibody
anti-Renin antibody for ELISA,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes Renin |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | Renin |
| Antigen Species | Human |
| Immunogen | Human Renin recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Renin |
| Alternate Names | REN; Renin; Angiotensinogenase; EC 3.4.23.15; Angiotensin-Forming Enzyme; Renin Precursor, Renal ; EC 3.4.23; ADTKD4; HNFJ2; RTD |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | REN |
| Gene Full Name | renin |
| Background | This gene encodes renin, an aspartic protease that is secreted by the kidneys. Renin is a part of the renin-angiotensin-aldosterone system involved in regulation of blood pressure, and electrolyte balance. This enzyme catalyzes the first step in the activation pathway of angiotensinogen by cleaving angiotensinogen to form angiotensin I, which is then converted to angiotensin II by angiotensin I converting enzyme. This cascade can result in aldosterone release, narrowing of blood vessels, and increase in blood pressure as angiotension II is a vasoconstrictive peptide. Transcript variants that encode different protein isoforms and that arise from alternative splicing and the use of alternative promoters have been described, but their full-length nature has not been determined. Mutations in this gene have been shown to cause hyperuricemic nephropathy familial juvenile 2, familial hyperproreninemia, and renal tubular dysgenesis. |
| Function | Renin is a highly specific endopeptidase, whose only known function is to generate angiotensin I from angiotensinogen in the plasma, initiating a cascade of reactions that produce an elevation of blood pressure and increased sodium retention by the kidney. |
| Cellular Localization | Membrane, Secreted |
| Calculated MW | 45 kDa |
| PTM | Cleavage on pair of basic residues, Disulfide bond, Glycoprotein, Zymogen |
Images (4) Click the Picture to Zoom In
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ARG43882 anti-Renin antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG43882 anti-Renin antibody at 2 μg/ml dilution.
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ARG43882 anti-Renin antibody WB image
Western blot: HepG2 and 293T stained with ARG43882 anti-Renin antibody at 1:5000 dilution.
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ARG43882 anti-Renin antibody IHC-P image
Immunohistochemistry: Mouse kidney adenocarcinoma stained with ARG43882 anti-Renin antibody at 2 μg/ml dilution.
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ARG43882 anti-Renin antibody IHC-P image
Immunohistochemistry: Rat colorectal adenocarcinoma stained with ARG43882 anti-Renin antibody at 2 μg/ml dilution.
