ARG40822
anti-REG3A antibody
anti-REG3A antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes REG3A |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC-P, WB |
| Specificity | This antibody might also react to REG3G based on sequence analysis. |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | REG3A |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 27-175 of Human REG3A (NP_002571.1). |
| Conjugation | Un-conjugated |
| Alternate Names | HIP; PAP; HIP/PAP; Regenerating islet-derived protein 3-alpha; PAP-H; REG-III; Hepatointestinal pancreatic protein; PBCGF; Human proislet peptide; REG3; INGAP; Regenerating islet-derived protein III-alpha; REG-3-alpha; Reg III-alpha; PAP1; Pancreatitis-associated protein 1 |
Application Instructions
| Application Suggestion |
|
||||||
|---|---|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse pancreas | ||||||
| Observed Size | 14.5 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | REG3A |
| Gene Full Name | regenerating islet-derived 3 alpha |
| Background | This gene encodes a pancreatic secretory protein that may be involved in cell proliferation or differentiation. It has similarity to the C-type lectin superfamily. The enhanced expression of this gene is observed during pancreatic inflammation and liver carcinogenesis. The mature protein also functions as an antimicrobial protein with antibacterial activity. Alternate splicing results in multiple transcript variants that encode the same protein.[provided by RefSeq, Nov 2014] |
| Function | Bactericidal C-type lectin which acts exclusively against Gram-positive bacteria and mediates bacterial killing by binding to surface-exposed carbohydrate moieties of peptidoglycan. Regulates keratinocyte proliferation and differentiation after skin injury via activation of EXTL3-PI3K-AKT signaling pathway. [UniProt] |
| Cellular Localization | Secreted. Note=Found in the apical region of pancreatic acinar cells. [UniProt] |
| Calculated MW | 19 kDa |
| PTM | Proteolytic processing by trypsin removes an inhibitory N-terminal propeptide and is essential for peptidoglycan binding and antibacterial activity. [UniProt] |
Images (2) Click the Picture to Zoom In
-
ARG40822 anti-REG3A antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Mouse brain stained with ARG40822 anti-REG3A antibody.
-
ARG40822 anti-REG3A antibody WB image
Western blot: 25 µg of Mouse pancreas lysate stained with ARG40822 anti-REG3A antibody at 1:1000 dilution.
