ARG11072
anti-Norepinephrine Transporter antibody [NET-05]
anti-Norepinephrine Transporter antibody [NET-05] for Western blot and Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [NET-05] recognizes Norepinephrine Transporter |
|---|---|
| Tested Reactivity | Ms, Rat |
| Species Does Not React With | Hu |
| Tested Application | WB |
| Specificity | This antibody recognizes Mouse and Rat NET. It does not recognize Human NET. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | NET-05 |
| Isotype | IGg2b |
| Target Name | Norepinephrine Transporter |
| Antigen Species | Mouse |
| Immunogen | KLH-conjugated synthetic peptide around the N-terminal region of Mouse Norepinephrine Transporter. |
| Conjugation | Un-conjugated |
| Alternate Names | SLC6A5; Solute carrier family 6 member 2; NAT1; Norepinephrine transporter; NET; Sodium-dependent noradrenaline transporter; NET1 |
Application Instructions
| Predict Reactivity Note | Sequence homology: Cow (92%); Cat, Human and non-human primate (85%) | ||||
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| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | This antibody is prepared by Ammonium Sulfate precipitation from hybridoma culture media followed by dialysis against PBS. |
| Buffer | PBS and 50% Glycerol. |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # O55192 Mouse Sodium-dependent noradrenaline transporter |
|---|---|
| Gene Symbol | SLC6A2 |
| Gene Full Name | solute carrier family 6 (neurotransmitter transporter), member 2 |
| Background | This gene encodes a member of the sodium:neurotransmitter symporter family. This member is a multi-pass membrane protein, which is responsible for reuptake of norepinephrine into presynaptic nerve terminals and is a regulator of norepinephrine homeostasis. Mutations in this gene cause orthostatic intolerance, a syndrome characterized by lightheadedness, fatigue, altered mentation and syncope. Alternatively spliced transcript variants encoding different isoforms have been identified in this gene.[provided by RefSeq, Feb 2010] |
| Function | Amine transporter. Terminates the action of noradrenaline by its high affinity sodium-dependent reuptake into presynaptic terminals. [UniProt] |
| Cellular Localization | Cell membrane; Multi-pass membrane protein. [UniProt] |
| Calculated MW | 69 kDa |
Images (1) Click the Picture to Zoom In
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ARG11072 anti-Norepinephrine Transporter antibody [NET-05] WB image
Western blot: Mouse cortex homogenate after a 1000xg spin to eliminate non-homegnized tissue fragments of wild type (WT) and NET knockout (NET KO) tissue. The blots were stained with ARG11072 anti-Norepinephrine Transporter antibody [NET-05].
