ARG40171

anti-Natriuretic Peptide Receptor C (NPR C) antibody

anti-Natriuretic Peptide Receptor C (NPR C) antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Overview

Product Description Goat Polyclonal antibody recognizes Natriuretic Peptide Receptor C (NPR C)
Tested Reactivity Hu
Predict Reactivity Ms, Rat, Cow, Dog, Pig
Tested Application IHC-P, WB
Host Goat
Clonality Polyclonal
Isotype IgG
Target Name Natriuretic Peptide Receptor C (NPR C)
Antigen Species Human
Immunogen Synthetic peptide around the C-terminus of Human Natriuretic Peptide Receptor C. (C-HRELREDSIRSHFS, NP_000899.1)
Conjugation Un-conjugated
Alternate Names GUCY2B; ANPRC; C5orf23; Atrial natriuretic peptide receptor 3; NPR-C; NPRC; Atrial natriuretic peptide receptor type C; Atrial natriuretic peptide clearance receptor; ANPR-C; ANP-C

Application Instructions

Application Suggestion
Tested Application Dilution
IHC-P2 - 10 µg/ml
WB1 - 3 µg/ml
Application Note WB: Recommend incubate at RT for 1h.
IHC-P: Antigen Retrieval: Microwaved or steamed tissue section in Citrate buffer (pH 6.0).
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Ammonium sulphate precipitation followed by affinity purification with immunogen.
Buffer Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA.
Preservative 0.02% Sodium azide
Stabilizer 0.5% BSA
Concentration 0.5 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 4883 Human NPR3

Swiss-port # P17342 Human Atrial natriuretic peptide receptor 3

Gene Symbol NPR3
Gene Full Name natriuretic peptide receptor 3
Background This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Feb 2011]
Function Receptor for the natriuretic peptide hormones, binding with similar affinities atrial natriuretic peptide NPPA/ANP, brain natriuretic peptide NPPB/BNP, and C-type natriuretic peptide NPPC/CNP. May function as a clearance receptor for NPPA, NPPB and NPPC, regulating their local concentrations and effects. May regulate diuresis, blood pressure and skeletal development. Does not have guanylate cyclase activity. [UniProt]
Cellular Localization Membrane; Single-pass type I membrane protein. [UniProt]
Calculated MW 60 kDa

Images (3) Click the Picture to Zoom In

  • ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human kidney tissue. Antigen Retrieval: Microwaved tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody at 2 µg/ml dilution followed by HRP-staining.

  • ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody WB image

    Western blot: 35 µg of Human placenta lysate (in RIPA buffer) stained with ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody at 1 µg/ml dilution and incubated at RT for 1 hour.

  • ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody IHC-P image

    Immunohistochemistry: Paraffin-embedded Human prostate tissue. Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). The tissue section was stained with ARG40171 anti-Natriuretic Peptide Receptor C (NPR C) antibody at 10 µg/ml dilution followed by AP-staining.