ARG44233
anti-MLLT10 / AF10 antibody
anti-MLLT10 / AF10 antibody for Flow cytometry,ICC/IF,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes MLLT10 / AF10 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | FACS, ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | MLLT10 / AF10 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human MLLT10 / AF10 |
| Conjugation | Un-conjugated |
| Protein Full Name | Protein AF-10 |
| Alternate Names | MLLT10; MLLT10 Histone Lysine Methyltransferase DOT1L Cofactor; AF10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia; Translocated To, 10; ALL1-Fused Gene From Chromosome 10 Protein; Protein AF-10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax (Drosophila) Homolog); Translocated To, 10; Myeloid/Lymphoid Or Mixed-Lineage Leukemia (Trithorax Homolog, Drosophila); Translocated To, 10; Type III AF10 Protein; Type IV AF10 Protein; Type I AF10 Protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MLLT10 |
| Gene Full Name | Mllt10 Histone Lysine Methyltransferase Dot1L Cofactor |
| Background | This gene encodes a transcription factor and has been identified as a partner gene involved in several chromosomal rearrangements resulting in various leukemias. Multiple transcript variants encoding different isoforms have been found for this gene. |
| Function | Probably involved in transcriptional regulation. In vitro or as fusion protein with KMT2A/MLL1 has transactivation activity. Binds to cruciform DNA. In cells, binding to unmodified histone H3 regulates DOT1L functions including histone H3 'Lys-79' dimethylation (H3K79me2) and gene activation. |
| Cellular Localization | Nucleus |
| Calculated MW | 113 kDa |
| PTM | Isopeptide bond, Phosphoprotein, Ubl conjugation |
Images (3) Click the Picture to Zoom In
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ARG44233 anti-MLLT10 / AF10 antibody ICC/IF image
Immunofluorescence: A549 stained with ARG44233 anti-MLLT10 / AF10 antibody at 5 μg/ml dilution.
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ARG44233 anti-MLLT10 / AF10 antibody WB image
Western blot: Rat testis stained with ARG44233 anti-MLLT10 / AF10 antibody at 0.5 μg/mL dilution.
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ARG44233 anti-MLLT10 / AF10 antibody WB image
Western blot: Mouse testis stained with ARG44233 anti-MLLT10 / AF10 antibody at 0.5 μg/mL dilution.
