ARG62535
anti-Lewis B antibody [LWB01(2-25LE)]
anti-Lewis B antibody [LWB01(2-25LE)] for IHC-Formalin-fixed paraffin-embedded sections and Human
Cancer antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [LWB01 (2-25LE)] recognizes Lewis B |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | LWB01 (2-25LE) |
| Isotype | IgG1 |
| Target Name | Lewis B |
| Antigen Species | Human |
| Immunogen | Human colorectal carcinoma cell line LS174T |
| Conjugation | Un-conjugated |
| Alternate Names | leB; Major airway glycoprotein; Lewis B blood group antigen; Tracheobronchial mucin; mucin; Mucin-5AC; LeB; MUC5; TBM; Gastric mucin; MUC-5AC; Mucin-5 subtype AC, tracheobronchial |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Colon |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified Antibody |
| Buffer | 1X PBS and 0.1% Sodium azide |
| Preservative | 0.1% Sodium azide |
| Concentration | 0.2 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | MUC5AC |
| Gene Full Name | mucin 5AC, oligomeric mucus/gel-forming |
| Function | Gel-forming glycoprotein of gastric and respiratoy tract epithelia that protects the mucosa from infection and chemical damage by binding to inhaled microrganisms and particles that are subsequently removed by the mucocilary system. [UniProt] |
| Research Area | Cancer antibody; Signaling Transduction antibody |
| Calculated MW | 586 kDa |
| PTM | C-, O- and N-glycosylated. O-glycosylated on the Thr-/Ser-rich tandem repeats. C-mannosylation in the Cys-rich subdomains may be required for proper folding of these regions and for export from the endoplasmic reticulum during biosynthesis. Proteolytic cleavage in the C-terminal is initiated early in the secretory pathway and does not involve a serine protease. The extent of cleavage is increased in the acidic parts of the secretory pathway. Cleavage generates a reactive group which could link the protein to a primary amide. |
Clone References
Glycosylation of mucins present in gastric juice: the effect of helicobacter pylori eradication treatment.
ELISA / Human
Genetic susceptibility to symptomatic norovirus infection in Nicaragua.
WB / Human
The effect of Helicobacter pylori eradication treatment on the MUC 1 and Lewis antigens level in human gastric juice: a preliminary study.
WB / Human
Conjunctival M cells selectively bind and translocate Maackia amurensis leukoagglutinin.
IHC / Guinea pig
Modification of Helicobacter pylori outer membrane protein expression during experimental infection of rhesus macaques.
IHC / Human
