ARG67218
anti-KDM5D / Jarid1D / SMCY antibody
anti-KDM5D / Jarid1D / SMCY antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes KDM5D / Jarid1D / SMCY |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | KDM5D / Jarid1D / SMCY |
| Antigen Species | Human |
| Immunogen | Recombinant protein corresponding to C-terminal region of human KDM5D / Jarid1D / SMCY. |
| Conjugation | Un-conjugated |
| Alternate Names | KDM5D; Lysine Demethylase 5D; KIAA0234; JARID1D; SMCY; HYA; HY; Jumonji, AT Rich Interactive Domain 1D (RBP2-Like); [Histone H3]-Trimethyl-L-Lysine(4) Demethylase 5D; Jumonji/ARID Domain-Containing Protein 1D; Lysine (K)-Specific Demethylase 5D; Lysine-Specific Demethylase 5D; Histocompatibility Y Antigen; Histone Demethylase JARID1D; Protein SmcY; H-Y; Epididymis Secretory Sperm Binding Protein; Selected Mouse CDNA On Y, Human Homolog Of; Jumonji, AT Rich Interactive Domain 1D; Smcy Homolog, Y-Linked (Mouse); SMC Homolog, Y Chromosome; Smcy Homolog, Y-Linked; EC 1.14.11.67; EC 1.14.11 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Powder |
|---|---|
| Purification | Protein A purified |
| Buffer | PBS |
| Reconstitution | Water |
| Concentration | 0.1 - 1.0 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | KDM5D |
| Gene Full Name | Lysine Demethylase 5D |
| Background | This gene encodes a protein containing zinc finger domains. A short peptide derived from this protein is a minor histocompatibility antigen which can lead to graft rejection of male donor cells in a female recipient. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Apr 2009] |
| Function | Histone demethylase that specifically demethylates 'Lys-4' of histone H3, thereby playing a central role in histone code. Does not demethylate histone H3 'Lys-9', H3 'Lys-27', H3 'Lys-36', H3 'Lys-79' or H4 'Lys-20'. Demethylates trimethylated and dimethylated but not monomethylated H3 'Lys-4'. May play a role in spermatogenesis. Involved in transcriptional repression of diverse metastasis-associated genes; in this function seems to cooperate with ZMYND8. Suppresses prostate cancer cell invasion. Regulates androgen receptor (AR) transcriptional activity by demethylating H3K4me3 active transcription marks. |
| Cellular Localization | Nucleus. [UniProt] |
| PTM | Isopeptide bond; Phosphoprotein; Ubl conjugation. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67218 anti-KDM5D / Jarid1D / SMCY antibody WB image
Western blot: KDM5D / Jarid1D / SMCY recombinant protein stained with ARG67218 anti-KDM5D / Jarid1D / SMCY antibody.
