ARG53935
anti-HLA A2 antibody [BB7.2] (PE)
anti-HLA A2 antibody [BB7.2] (PE) for Flow cytometry and Human
Immune System antibody
Publication1
Overview
| Product Description | PE-conjugated Mouse Monoclonal antibody [BB7.2] recognizes HLA A2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | FACS |
| Specificity | The clone BB7.2 recognizes an epitope at the C-terminus of alpha-2 helix and a turn on one of the underlying beta strands within the human HLA-A2 histocompatibility antigen. |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | BB7.2 |
| Isotype | IgG2b |
| Target Name | HLA A2 |
| Immunogen | HLA-A2 solubilised by papain_x000D_ |
| Conjugation | PE |
| Alternate Names | MHC class I antigen A*1; HLAA; HLA class I histocompatibility antigen, A-1 alpha chain |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with R-Phycoerythrin (PE) under optimum conditions. The conjugate is purified by size-exclusion chromatography and adjusted for direct use. No reconstitution is necessary. |
| Buffer | PBS, 15 mM Sodium azide and 0.2% (w/v) high-grade protease free BSA |
| Preservative | 15 mM Sodium azide |
| Stabilizer | 0.2% (w/v) high-grade protease free BSA |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P30443 Human HLA class I histocompatibility antigen, A-1 alpha chain |
|---|---|
| Gene Symbol | HLA-A |
| Gene Full Name | major histocompatibility complex, class I, A |
| Background | HLA-A2 (44 kDa) is the most frequent HLA-A allele in human ethnic populations. HLA-A, together with HLA-B and HLA-C, represent human HLA class I major histocompatibility (MHC) antigens. These intrinsic membrane glycoproteins are expressed on nucleated cells and noncovalently associate with an invariant beta2 microglobulin. They carry foreign determinants important for immune recognition by cytotoxic T cells, thus important for anti-viral and anti-tumour defence._x000D_ |
| Function | Involved in the presentation of foreign antigens to the immune system. [UniProt] |
| Research Area | Immune System antibody |
| Calculated MW | 40 kDa |
| PTM | Polyubiquitinated in a post ER compartment by interaction with human herpesvirus 8 MIR1 protein. This targets the protein for rapid degradation via the ubiquitin system (By similarity). |
Images (1) Click the Picture to Zoom In
-
ARG53935 anti-HLA A2 antibody [BB7.2] (PE) FACS image
Flow Cytometry: Human peripheral blood cells stained with ARG53935 anti-HLA A2 antibody [BB7.2] (PE).
Specific References
STING agonist diABZI enhances the cytotoxicity of T cell towards cancer cells
FACS / Human
