ARG44201
anti-HB EGF antibody
anti-HB EGF antibody for Western blot and Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes HB EGF |
|---|---|
| Tested Reactivity | Ms, Rat |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | HB EGF |
| Antigen Species | Mouse |
| Immunogen | Recombinant protein of Mouse HB EGF |
| Conjugation | Un-conjugated |
| Protein Full Name | Proheparin-binding EGF-like growth factor |
| Alternate Names | HBEGF; Heparin Binding EGF Like Growth Factor; HEGFL; DTR; DTS; Diphtheria Toxin Receptor (Heparin-Binding Epidermal Growth Factor-Like Growth Factor); Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor); Proheparin-Binding EGF-Like Growth Factor; Heparin-Binding Epidermal Growth Factor; Heparin-Binding EGF-Like Growth Factor; DTSF |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.9% NaCl, 0.2% Na2HPO4, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | HBEGF |
|---|---|
| Gene Full Name | Heparin-Binding Egf-Like Growth Factor |
| Background | Enables growth factor activity and heparin binding activity. Involved in several processes, including epidermal growth factor receptor signaling pathway; positive regulation of protein kinase B signaling; and positive regulation of wound healing. Located in cell surface and extracellular space. Implicated in glomerulosclerosis and perinatal necrotizing enterocolitis. |
| Function | Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor. |
| Cellular Localization | Cell membrane, Membrane, Secreted |
| Calculated MW | 23 kDa |
| PTM | Disulfide bond, Glycoprotein |
Images (2) Click the Picture to Zoom In
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ARG44201 anti-HB EGF antibody WB image
Western blot: Rat heart stained with ARG44201 anti-HB EGF antibody at 0.5 μg/mL dilution.
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ARG44201 anti-HB EGF antibody WB image
Western blot: Mouse heart stained with ARG44201 anti-HB EGF antibody at 0.5 μg/mL dilution.
