ARG58714
anti-GAS2 antibody
anti-GAS2 antibody for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes GAS2 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | GAS2 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-100 of Human GAS2 (NP_005247.1). |
| Conjugation | Un-conjugated |
| Alternate Names | Growth arrest-specific protein 2; GAS-2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | Mouse kidney | ||||||
| Observed Size | 37 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | GAS2 |
| Gene Full Name | growth arrest-specific 2 |
| Background | The protein encoded by this gene is a caspase-3 substrate that plays a role in regulating microfilament and cell shape changes during apoptosis. It can also modulate cell susceptibility to p53-dependent apoptosis by inhibiting calpain activity. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jan 2009] |
| Function | May play a role in apoptosis by acting as a cell death substrate for caspases. Is cleaved during apoptosis and the cleaved form induces dramatic rearrangements of the actin cytoskeleton and potent changes in the shape of the affected cells. May be involved in the membrane ruffling process (By similarity). [UniProt] |
| Cellular Localization | Cytoplasm, cytoskeleton, Membrane, Peripheral membrane protein. [UniProt] |
| Calculated MW | 35 kDa |
| PTM | Cleaved, during apoptosis, on a specific aspartic residue by caspases. Phosphorylated on serine residues during the G0-G1 transition phase. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG58714 anti-GAS2 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human liver cancer stained with ARG58714 anti-GAS2 antibody at 1:200 dilution.
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ARG58714 anti-GAS2 antibody WB image
Western blot: 25 µg of Mouse kidney lysate stained with ARG58714 anti-GAS2 antibody at 1:1000 dilution.
