ARG45049
anti-Fibrillin 1 antibody [RM463]
anti-Fibrillin 1 antibody [RM463] for IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit monoclonal antibody [RM463] recognizes Fibrillin 1. |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P, WB |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | RM463 |
| Isotype | IgG |
| Target Name | Fibrillin 1 |
| Antigen Species | Human |
| Conjugation | Un-conjugated |
| Alternate Names | MASS ; OCTD ; SGS ; FBN ; Fibrillin-1 ; Asprosin ; MFS1 ; WMS ; Epididymis Secretory Sperm Binding Protein ; Fibrillin 1 (Marfan Syndrome) ; Fibrillin-1 Preproprotein ; Marfan Syndrome ; Fibrillin 15 ; GPHYSD2 ; ACMICD ; ECTOL1 ; MFLS ; SSKS ; WMS2 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Protein A affinity purified. |
| Buffer | PBS with 50% Glycerol, 1% BSA and 0.09% sodium azide |
| Preservative | 0.09% sodium azide |
| Stabilizer | 50% Glycerol, 1% BSA and 0.09% |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Background | This gene encodes a member of the fibrillin family of proteins. The encoded preproprotein is proteolytically processed to generate two proteins including the extracellular matrix component fibrillin-1 and the protein hormone asprosin. Fibrillin-1 is an extracellular matrix glycoprotein that serves as a structural component of calcium-binding microfibrils. These microfibrils provide force-bearing structural support in elastic and nonelastic connective tissue throughout the body. Asprosin, secreted by white adipose tissue, has been shown to regulate glucose homeostasis. Mutations in this gene are associated with Marfan syndrome and the related MASS phenotype, as well as ectopia lentis syndrome, Weill-Marchesani syndrome, Shprintzen-Goldberg syndrome and neonatal progeroid syndrome. [provided by RefSeq, Apr 2016] |
| Function | Structural component of the 10-12 nm diameter microfibrils of the extracellular matrix, which conveys both structural and regulatory properties to load-bearing connective tissues. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG45049 anti-Fibrillin 1 antibody [RM463] IHC-P image
Immunohistochemistry: Human breast tissue stained with ARG45049 anti-Fibrillin 1 antibody [RM463] at 1:100 dilution.
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ARG45049 anti-Fibrillin 1 antibody [RM463] WB image
Western blot: Human plasma stained with ARG45049 anti-Fibrillin 1 antibody [RM463] at 1:25000 dilution.
