ARG58608
anti-ETS2 antibody
anti-ETS2 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ETS2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Bov |
| Tested Application | FACS, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ETS2 |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide between aa. 146-173 of Human ETS2. |
| Conjugation | Un-conjugated |
| Alternate Names | Protein C-ets-2; ETS2IT1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | MCF7 |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | ETS2 |
| Gene Full Name | v-ets avian erythroblastosis virus E26 oncogene homolog 2 |
| Background | This gene encodes a transcription factor which regulates genes involved in development and apoptosis. The encoded protein is also a protooncogene and shown to be involved in regulation of telomerase. A pseudogene of this gene is located on the X chromosome. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2012] |
| Function | Transcription factor activating transcription. Binds specifically the DNA GGAA/T core motif (Ets-binding site or EBS) in gene promoters and stimulates transcription. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 53 kDa |
| PTM | Phosphorylation by CDK10 at Ser-220 and Ser-225 creates a phosphodegron that targets ETS2 for proteasomal degradation. [UniProt] |
Images (3) Click the Picture to Zoom In
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ARG58608 anti-ETS2 antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human brain tissue stained with ARG58608 anti-ETS2 antibody.
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ARG58608 anti-ETS2 antibody WB image
Western blot: 35 µg of MCF7 cell lysate stained with ARG58608 anti-ETS2 antibody.
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ARG58608 anti-ETS2 antibody FACS image
Flow Cytometry: MCF7 cells stained with ARG58608 anti-ETS2 antibody (right histogram) or without primary antibody as control (left histogram), followed by incubation with FITC labelled secondary antibody.
