ARG66227

anti-CD273 / PD-L2 antibody [24F.10C12]

anti-CD273 / PD-L2 antibody [24F.10C12] for CyTOF®-candidate,Flow cytometry,Functional study,IHC-Frozen sections and Human

Overview

Product Description Mouse Monoclonal antibody [24F.10C12] recognizes CD273 / PD-L2
Tested Reactivity Hu
Tested Application CyTOF®-candidate, FACS, FuncSt, IHC-Fr
Specificity This antibody recognizes CD273 / PD-L2 (also known as B7-DC), a 25 kDa type I transmembrane protein expressed by dendritic cells, activated monocytes and T cells, heart, first trimester placenta, lung and liver, as well as in Hodgkin's lymphoma cells and primary mediastinal B cell lymphoma (PMBL).
Host Mouse
Clonality Monoclonal
Clone 24F.10C12
Isotype IgG2a
Target Name CD273 / PD-L2
Antigen Species Human
Immunogen Human CD273.
Conjugation Un-conjugated
Alternate Names B7DC; bA574F11.2; PDL2; CD antigen CD273; PD-L2; Programmed cell death 1 ligand 2; CD273; Btdc; PDCD1L2; Programmed death ligand 2; Butyrophilin B7-DC; B7-DC; PD-1 ligand 2; PDCD1 ligand 2

Application Instructions

Application Suggestion
Tested Application Dilution
CyTOF®-candidateAssay-dependent
FACS1 - 4 µg/ml
FuncStAssay-dependent
IHC-FrAssay-dependent
Application Note Functional study: anti-CD273 / PD-L2 antibody [24F.10C12] can be used to block PD-1 binding to its ligand.
* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form Liquid
Purification Purification with Protein A.
Purity > 95% (by SDS-PAGE)
Buffer PBS (pH 7.4) and 15 mM Sodium azide.
Preservative 15 mM Sodium azide
Concentration 1 mg/ml
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 80380 Human PDCD1LG2

Swiss-port # Q9BQ51 Human Programmed cell death 1 ligand 2

Gene Symbol PDCD1LG2
Gene Full Name programmed cell death 1 ligand 2
Function Involved in the costimulatory signal, essential for T-cell proliferation and IFNG production in a PDCD1-independent manner. Interaction with PDCD1 inhibits T-cell proliferation by blocking cell cycle progression and cytokine production (By similarity). [UniProt]
Highlight Related products:
PD-L2 antibodies; PD-L2 ELISA Kits; Anti-Mouse IgG secondary antibodies;
Related news:
CyTOF-candidate Antibodies
The best solution for PD-1/PD-L1 research
Calculated MW 31 kDa