The best solution for PD-1/PD-L1 research
The best solution for PD-1/PD-L1 research
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PD-1 is an immune checkpoint protein expressed on the surface of T cells. When PD-1 binds to its ligand PD-L1, an inhibitory signal is transmitted to suppress the cytotoxicity of T cells. Various types of cancer cells overexpress PD-L1 to evade T cell immunity. Further understanding of PD-1/PD-L1 molecular mechanisms is the research focus of cancer immunity. In addition to membrane-bound forms, soluble PD-1 and PD-L1 (sPD-L1 and sPD-1) have been revealed. The soluble forms increase the complexity of PD-1/PD-L1 signaling. sPD-L1 is produced from tumor cells and can suppress T cell activity. Elevated sPD-L1 level is associated with poorer prognosis. In contrast, sPD-1 is produced via alternative splicing and can improves the anti-tumor immunity by antagonize the inhibitory effect of PD-L1. The levels of sPD-1 and sPD-L1 are potential biomarker for the prediction of prognosis and treatment responses. arigo offers quality antibodies and ELISA kits to facilitate the understanding of the mechanism and regulation of PD-1/PD-L1 pathway in either human or mouse samples. |
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Best PD-L1 antibody for cancer pathology |
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IHC result is as good as the clone that
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IHC result is better than
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Best PD-1 and PD-L1 antibodies for studying PD-1/PD-L1 pathway |
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PD-1 antibody [SQab1732] (ARG66243) |
PD-L1 antibody (ARG55930) |
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Best ELISA kits for detecting sPD-1 and sPD-L1 |
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arigo offers specific and sensitive ELISA kits for detecting sPD-1 and sPD-L1 in samples from patients or mouse animal models. |
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* The most sensitive PD-1 ELISA kits in the market |
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Human PD-1 ELISA Kit (ARG81360) |
Mouse PD-1 ELISA Kit (ARG81342) |
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* The specific PD-L1 ELISA kits |
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Human PD-L1 ELISA Kit (ARG81929) |
Mouse PD-L1 ELISA Kit (ARG81930) |
* Human PD-L2 ELISA Kit (ARG81580) is also available.
