ARG42078
anti-BMP1 antibody
anti-BMP1 antibody for ICC/IF,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes BMP1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | BMP1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human BMP1. |
| Conjugation | Un-conjugated |
| Alternate Names | OI13; Procollagen C-proteinase; PCP; PCOLC; PCP2; BMP-1; Bone morphogenetic protein 1; Mammalian tolloid protein; TLD; EC 3.4.24.19; mTld |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||
| Positive Control | U-251 MG | ||||||
| Observed Size | ~ 95 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide. |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | BMP1 |
| Gene Full Name | bone morphogenetic protein 1 |
| Background | This gene encodes a protein that is capable of inducing formation of cartilage in vivo. Although other bone morphogenetic proteins are members of the TGF-beta superfamily, this gene encodes a protein that is not closely related to other known growth factors. This gene is expressed as alternatively spliced variants that share an N-terminal protease domain but differ in their C-terminal region. [provided by RefSeq, Aug 2008] |
| Function | Cleaves the C-terminal propeptides of procollagen I, II and III. Induces cartilage and bone formation. May participate in dorsoventral patterning during early development by cleaving chordin (CHRD). Responsible for the proteolytic activation of lysyl oxidase LOX. [UniProt] |
| Cellular Localization | Golgi apparatus, trans-Golgi network. Secreted, extracellular space, extracellular matrix. Note=Co-localizes with POSTN in the Golgi. [UniProt] |
| Calculated MW | 111 kDa |
| PTM | Proteolytically activated in the trans-Golgi network by furin-like/paired basic proprotein convertases, cleavage is not required for secretion. [UniProt] |
Images (2) Click the Picture to Zoom In
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ARG42078 anti-BMP1 antibody ICC/IF image
Immunofluorescence: 4% Paraformaldehyde-fixed, 0.1% Triton X-100 permeabilized A549 cells stained with ARG42078 anti-BMP1 antibody (green) at 1:25 dilution. Dylight® 554 Phalloidin (red) for cytoplasmic actin staining. DAPI (blue) for nuclear staining.
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ARG42078 anti-BMP1 antibody WB image
Western blot: 20 µg of U-251 MG whole cell lysate stained with ARG42078 anti-BMP1 antibody at 1:2000 dilution.
