ARG44041
anti-AMBRA1 antibody
anti-AMBRA1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes AMBRA1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | AMBRA1 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein containing a sequence corresponding to amino acids 1109-1208 of Human Ambra1 (NP_060219.2). |
| Conjugation | Un-conjugated |
| Alternate Names | DCAF3; Activating molecule in BECN1-regulated autophagy protein 1; WDR94 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% sodium azide and 50% Glycerol. |
| Preservative | 0.02% sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # A2AH22 Mouse Activating molecule in BECN1-regulated autophagy protein 1 Swiss-port # Q9C0C7 Human Activating molecule in BECN1-regulated autophagy protein 1 |
|---|---|
| Gene Symbol | AMBRA1 |
| Gene Full Name | autophagy/beclin-1 regulator 1 |
| Background | Enables GTPase binding activity and ubiquitin protein ligase binding activity. Involved in macroautophagy; positive regulation of phosphatidylinositol 3-kinase activity; and response to mitochondrial depolarisation. Located in cytosol. Colocalizes with mitochondrion. Biomarker of multiple system atrophy. |
| Function | Regulates autophagy and development of the nervous system. Involved in autophagy in controlling protein turnover during neuronal development, and in regulating normal cell survival and proliferation (By similarity). [UniProt] |
| Cellular Localization | Autophagosome. Note: Localizes also to discrete punctae along the ciliary axoneme. [UniProt] |
| Calculated MW | 143 kDa |
Images (4) Click the Picture to Zoom In
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ARG44041 anti-AMBRA1 antibody IHC-P image
Immunohistochemistry: Rat lung stained with ARG44041 anti-AMBRA1 antibody at 1:100 dilution.
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ARG44041 anti-AMBRA1 antibody ICC/IF image
Immunofluorescence: NIH/3T3 stained with ARG44041 anti-AMBRA1 antibody at 1:50 dilution.
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ARG44041 anti-AMBRA1 antibody WB image
Western blot: PANC-1 stained with ARG44041 anti-AMBRA1 antibody at 1:800 dilution.
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ARG44041 anti-AMBRA1 antibody IHC-P image
Immunohistochemistry: Mouse lung stained with ARG44041 anti-AMBRA1 antibody at 1:100 dilution.
