ARG41637
anti-ABCG1 antibody
anti-ABCG1 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes ABCG1 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Hm |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | ABCG1 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide corresponding to aa. 627-647 of Human ABCG1. (ETCHFQKSEAILRELDVENAK) |
| Conjugation | Un-conjugated |
| Alternate Names | White protein homolog; WHITE1; ATP-binding cassette transporter 8; ABC8; ATP-binding cassette sub-family G member 1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | ~ 77 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl, 0.05% Thimerosal, 0.05% Sodium azide and 5% BSA. |
| Preservative | 0.05% Thimerosal and 0.05% Sodium azide |
| Stabilizer | 5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P45844 Human ATP-binding cassette sub-family G member 1 |
|---|---|
| Gene Symbol | ABCG1 |
| Gene Full Name | ATP-binding cassette, sub-family G (WHITE), member 1 |
| Background | The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the White subfamily. It is involved in macrophage cholesterol and phospholipids transport, and may regulate cellular lipid homeostasis in other cell types. Six alternative splice variants have been identified. [provided by RefSeq, Jul 2008] |
| Function | Transporter involved in macrophage lipid homeostasis. Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. [UniProt] |
| Cellular Localization | Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus membrane; Multi-pass membrane protein. Note=Predominantly localized in the intracellular compartments mainly associated with the endoplasmic reticulum (ER) and Golgi membranes. [UniProt] |
| Calculated MW | 76 kDa |
| PTM | Palmitoylation at Cys-315 seems important for trafficking from the endoplasmic reticulum. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG41637 anti-ABCG1 antibody WB image
Western blot: 40 µg of U87, SMMC-7721, HeLa, COLO320 and MCF7 whole cell lysates stained with ARG41637 anti-ABCG1 antibody at 0.5 µg/ml dilution.
