ARG45406
anti-AATF antibody
anti-AATF antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes AATF |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | AATF |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human AATF. |
| Conjugation | Un-conjugated |
| Alternate Names | BFR2; Apoptosis-antagonizing transcription factor; CHE1; CHE-1; Rb-binding protein Che-1; Protein AATF; DED |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 95 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | AATF |
| Gene Full Name | apoptosis antagonizing transcription factor |
| Background | The protein encoded by this gene was identified on the basis of its interaction with MAP3K12/DLK, a protein kinase known to be involved in the induction of cell apoptosis. This gene product contains a leucine zipper, which is a characteristic motif of transcription factors, and was shown to exhibit strong transactivation activity when fused to Gal4 DNA binding domain. Overexpression of this gene interfered with MAP3K12 induced apoptosis. [provided by RefSeq, Jul 2008] |
| Function | Part of the small subunit (SSU) processome, first precursor of the small eukaryotic ribosomal subunit. During the assembly of the SSU processome in the nucleolus, many ribosome biogenesis factors, an RNA chaperone and ribosomal proteins associate with the nascent pre-rRNA and work in concert to generate RNA folding, modifications, rearrangements and cleavage as well as targeted degradation of pre-ribosomal RNA by the RNA exosome. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 63 kDa |
| PTM | Hyperphosphorylated during the G1/S phase transition. [UniProt] |
Images (4) Click the Picture to Zoom In
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ARG45406 anti-AATF antibody ICC/IF image
Immunofluorescence: A549 stained with ARG45406 anti-AATF antibody at 5 μg/ml dilution.
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ARG45406 anti-AATF antibody WB image
Western blot: 293T stained with ARG45406 anti-AATF antibody at 0.5 μg/ml dilution.
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ARG45406 anti-AATF antibody ICC/IF image
Immunofluorescence: Rat brain stained with ARG45406 anti-AATF antibody at 5 μg/ml dilution.
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ARG45406 anti-AATF antibody IHC-P image
Immunohistochemistry: Mouse cerebellum stained with ARG45406 anti-AATF antibody at 2 μg/ml dilution.
