ARG30233
Phospho Bcl XL Antibody Duo (Total, pS62)
Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody
Component
| Cat No | Component Name | Host clonality | Reactivity | Application | Package |
|---|---|---|---|---|---|
| ARG51569 | anti-Bcl XL phospho (Ser62) antibody | Rabbit pAb | Hu, Ms, Rat | ICC/IF, IHC-P, WB | 50 μl |
| ARG51057 | anti-Bcl XL antibody | Rabbit pAb | Hu, Ms, Rat | WB | 50 μl |
Overview
| Product Description | Members of the Bcl family of proteins are important regulators of programmed cell death pathways with individual members that can suppress (eg Bcl2, Bcl-XL) or promote (eg Bax, Bad) apoptosis. BCL-XL is a transmembrane molecule in the mitochondria, acts as a pro-survival protein by preventing the release of mitochondrial contents such as Cytochrome C which would lead to caspase activation. Ser62 residue of BCL-XL protein was found to be the major site of BCL-XL protein phosphorylation. This phosphorylation induced by microtubule inhibitors plays a key pro-apoptotic role in part by disabling the ability of Bcl-xL to bind Bax. Upreti et al. 2008. J Biol Chem 283(51): 35517 |
|---|---|
| Target Name | Bcl XL |
| Alternate Names | Phospho Bcl XL antibody; Bcl XL antibody; Bcl XL phospho (Ser62) antibody |
Properties
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
|---|---|
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Full Name | Phospho Bcl XL Antibody Duo (Total, pS62) |
|---|---|
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody; Cell Death antibody; Metabolism antibody; Signaling Transduction antibody |
Images (5) Click the Picture to Zoom In
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ARG51057 anti-BCL-XL antibody WB image
Western Blot: extracts from 293 and HeLa cells stained with anti-BCL-XL antibody ARG51057.
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ARG51569 anti-BCL-XL phospho (Ser62) antibody ICC/IF image
Immunofluorescence: methanol-fixed HeLa cells stained with anti-BCL-XL (phospho Ser62) antibody ARG51569, Red).
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ARG51569 anti-BCL-XL phospho (Ser62) antibody IHC-P image
Immunohistochemistry: paraffin-embedded human breast carcinoma tissue stained with anti-BCL-XL (phospho Ser62) antibody ARG51569).
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ARG51569 anti-BCL-XL phospho (Ser62) antibody WB image
Western Blot: extracts from HeLa cells untreated or treated with EGF stained with anti-BCL-XL (phospho Ser62) antibody ARG51569.
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ARG51569 anti-BCL-XL phospho (Ser62) antibody WB image
Western Blot: extracts from HeLa cells, treated with Noc or calf intestinal phosphatase (CIP), stained with anti-BCL-XL (phospho Ser62) antibody ARG51569.
