ARG83444
Human IL36RN ELISA Kit
Human IL36RN ELISA Kit for ELISA and Human
Overview
| Product Description | ARG83444 Human IL36RN ELISA Kit is an Enzyme Immunoassay kit for the quantification of Human IL36RN in Serum, plasma and cell culture supernatants., Tissue Homogenates |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA |
| Target Name | IL36RN |
| Conjugation | HRP |
| Conjugation Note | Substrate: TMB and read at 450 nm. |
| Sensitivity | 50 pg/ml |
| Sample Type | Serum, plasma and cell culture supernatants., Tissue Homogenates |
| Standard Range | 93.7 - 6000 pg/ml |
| Sample Volume | 100 µl |
| Precision | Intra-Assay CV: < 10% Inter-Assay CV: < 10% |
| Alternate Names | IL36RN; Interleukin 36 Receptor Antagonist; IL1HY1; IL1RP3; FIL1D; IL1L1; Interleukin-1 Receptor Antagonist Homolog 1; Interleukin-1 HY1; FIL1(DELTA); IL-1F5; IL36RA; IL1F5; FIL1; Interleukin-36 Receptor Antagonist Protein; Interleukin 1 Family, Member 5 (Delta); Interleukin-1-Like Protein 1; IL-1 Related Protein 3; IL-1ra Homolog 1; MGC29840; IL-36Ra; IL-1F5 (IL-1HY1, FIL1-Delta, IL-1RP3, IL-1L1, IL-1-Delta); IL1F5 (Canonical Product IL-1F5a); Family Of Interleukin 1-Delta; Interleukin-1 Family Member 5; IL-1-Related Protein 3; Interleukin-1 Delta; FIL1 Delta; IL-1 Delta; PSORS14; IL-1RP3; IL-1HY1; IL-1L1; PSORP |
Application Instructions
| Assay Time | 3.5 hours |
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Properties
| Form | 96 well |
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| Storage Instruction | Store the kit at 4°C. Keep microplate wells sealed in a dry bag with desiccants. Do not expose test reagents to heat, sun or strong light during storage and usage. Please refer to the product user manual for detail temperatures of the components. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UBH0 Human Interleukin-36 receptor antagonist protein |
|---|---|
| Gene Symbol | IL36RN |
| Gene Full Name | Interleukin 36 Receptor Antagonist |
| Background | The protein encoded by this gene is a member of the interleukin 1 cytokine family. This cytokine was shown to specifically inhibit the activation of NF-kappaB induced by interleukin 1 family, member 6 (IL1F6). This gene and eight other interleukin 1 family genes form a cytokine gene cluster on chromosome 2. Two alternatively spliced transcript variants encoding the same protein have been reported. |
| Function | Inhibits the activity of interleukin-36 (IL36A,IL36B and IL36G) by binding to receptor IL1RL2 and preventing its association with the coreceptor IL1RAP for signaling. Part of the IL-36 signaling system that is thought to be present in epithelial barriers and to take part in local inflammatory response; similar to the IL-1 system with which it shares the coreceptor. Proposed to play a role in skin inflammation. May be involved in the innate immune response to fungal pathogens, such as Aspergillus fumigatus. May activate an anti-inflammatory signaling pathway by recruiting SIGIRR. |
| Cellular Localization | Cytoplasm, Secreted |
| PTM | Disulfide bond |
Images (1) Click the Picture to Zoom In
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ARG83444 Human IL36RN ELISA Kit standard curve image
ARG83444 Human IL36RN ELISA Kit results of a typical standard run with optical density reading at 450 nm.
| Title | Download Link |
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| ARG83444 Human IL36RN ELISA Kit User manual |
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