ARG52418
anti-p90 RSK2 antibody
anti-p90 RSK2 antibody for Western blot and Human
Gene Regulation antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes p90 RSK2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms, Rat, Bov, Chk, Dog |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | p90 RSK2 |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide corresponding to amino acid residues from the C-terminal region of p90 RSK2 conjugated to KLH |
| Conjugation | Un-conjugated |
| Alternate Names | Ribosomal S6 kinase 3; S6K-alpha2; MAPKAPK-1c; MAPKAP kinase 1c; RSK; HU-2; S6K-alpha; p90RSK2; RSK-3; p90-RSK 2; MAPKAPK1C; p90-RSK3; pp90RSK3; 90 kDa ribosomal protein S6 kinase 2; MAP kinase-activated protein kinase 1c; EC 2.7.11.1; Ribosomal protein S6 kinase alpha-2; RSK3; S6K-alpha-2; MAPK-activated protein kinase 1c |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | Specific for ~90k RSK2 protein. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity Purified |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 0.1 mg/ml BSA and 50% Glycerol |
| Stabilizer | 0.1 mg/ml BSA, 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q15349 Human Ribosomal protein S6 kinase alpha-2 |
|---|---|
| Gene Symbol | RPS6KA2 |
| Gene Full Name | ribosomal protein S6 kinase, polypeptide 2 |
| Background | The p90 ribosomal S6 kinases (RSK)1–4 are downstream members of the extracellular signal-regulated kinase (ERK)/MAPK cascade. The loss of RSK2 activity in humans leads to Coffin–Lowry syndrome, which is characterized by mental retardation and growth deficits (Hanauer and Young, 2002). Recent work suggests that RSK2 exerts a tonic regulation on G-protein coupled signaling (Sheffler et al., 2006). |
| Research Area | Gene Regulation antibody; Signaling Transduction antibody |
| Calculated MW | 83 kDa |
| PTM | Activated by phosphorylation at Ser-218 by PDPK1. Autophosphorylated on Ser-377, as part of the activation process. May be phosphorylated at Thr-356 and Ser-360 by MAPK1/ERK2 and MAPK3/ERK1 (By similarity). N-terminal myristoylation results in an activated kinase in the absence of added growth factors. |
Images (1) Click the Picture to Zoom In
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ARG52418 anti-p90 RSK2 antibody WB image
Western blot: HeLa cell lysate showing specific immunolabeling of the ~90 kDa of RSK2 protein stained with ARG52418 anti-p90 RSK2 antibody.
