ARG45058
anti-p70 S6 Kinase phospho (Ser398) antibody
anti-p70 S6 Kinase phospho (Ser398) antibody for Western blot and Drosophila
Overview
| Product Description | Rabbit Polyclonal antibody recognizes p70 S6 Kinase phospho (Ser398) |
|---|---|
| Tested Reactivity | Drosophila |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | p70 S6 Kinase |
| Antigen Species | Drosophila |
| Immunogen | Synthetic phospho-peptide corresponding to amino acid residues surrounding Thr398 of Drosophila p70 S6 Kinase |
| Conjugation | Un-conjugated |
| Alternate Names | RPS6KB1; Ribosomal Protein S6 Kinase B1; S6K1; P70(S6K)-Alpha; STK14A; PS6K; S6K; Serine/Threonine-Protein Kinase 14A; Ribosomal Protein S6 Kinase Beta-1; Ribosomal Protein S6 Kinase I; EC 2.7.11.1; S6K-Beta-1; P70 S6KA; Ribosomal Protein S6 Kinase, 70kDa, Polypeptide 1; Ribosomal Protein S6 Kinase, 70kD, Polypeptide 1; 70 KDa Ribosomal Protein S6 Kinase 1; Serine/Threonine Kinase 14 Alpha; P70 Ribosomal S6 Kinase Alpha; P70 S6 Kinase Alpha; P70 S6K-Alpha; P70-Alpha; P70-S6K 1; EC 2.7.11; P70-S6K; P70S6K1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified. |
| Buffer | 10 mM HEPES (pH 7.5), 150 mM NaCl, 50% glycerol and 0.01% BSA. |
| Stabilizer | 50% Glycerol and 0.01% BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Gene Symbol | RPS6KB1 |
|---|---|
| Gene Full Name | Ribosomal Protein S6 Kinase B1 |
| Background | This gene encodes a member of the ribosomal S6 kinase family of serine/threonine kinases. The encoded protein responds to mTOR (mammalian target of rapamycin) signaling to promote protein synthesis, cell growth, and cell proliferation. Activity of this gene has been associated with human cancer. Alternatively spliced transcript variants have been observed. The use of alternative translation start sites results in isoforms with longer or shorter N-termini which may differ in their subcellular localizations. There are two pseudogenes for this gene on chromosome 17. [provided by RefSeq, Jan 2013] |
| Function | Following activation by mTORC1, phosphorylates EPRS and thereby plays a key role in fatty acid uptake by adipocytes and also most probably in interferon-gamma-induced translation inhibition. [UniProt] |
| Cellular Localization | Cytoplasm, Membrane, Mitochondrion, Mitochondrion outer membrane, Nucleus, Synapse, Synaptosome. [UniProt] |
| Calculated MW | 60 kDa |
| PTM | Acetylation, Phosphoprotein. [UniProt] |
