Overview

Product Description	Rabbit Polyclonal antibody recognizes mGluR2
Tested Reactivity	Hu, Ms, Rat
Tested Application	ICC/IF, IHC-P, WB
Host	Rabbit
Clonality	Polyclonal
Isotype	IgG
Target Name	mGluR2
Antigen Species	Human
Immunogen	Synthetic peptide of Human mGluR2.
Conjugation	Un-conjugated
Alternate Names	GPRC1B; mGlu2; mGluR2; Metabotropic glutamate receptor 2; GLUR2; MGLUR2

Application Instructions

Application Suggestion	Tested Application Dilution ICC/IF 1:50 - 1:200 IHC-P 1:50 - 1:200 WB 1:5000 - 1:10000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Positive Control	Mouse brain
Observed Size	~ 97 kDa

Properties

Form	Liquid
Purification	Affinity purified.
Buffer	PBS (pH 7.4), 150 mM NaCl, 0.02% Sodium azide and 50% Glycerol.
Preservative	0.02% Sodium azide
Stabilizer	50% Glycerol
Storage Instruction	For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 108068 Mouse GRM2 GeneID: 24415 Rat GRM2 GeneID: 2912 Human GRM2 Swiss-port # P31421 Rat Metabotropic glutamate receptor 2 Swiss-port # Q14416 Human Metabotropic glutamate receptor 2 Swiss-port # Q14BI2 Mouse Metabotropic glutamate receptor 2 More
Gene Symbol	GRM2
Gene Full Name	glutamate receptor, metabotropic 2
Background	L-glutamate is the major excitatory neurotransmitter in the central nervous system and activates both ionotropic and metabotropic glutamate receptors. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. The metabotropic glutamate receptors are a family of G protein-coupled receptors, that have been divided into 3 groups on the basis of sequence homology, putative signal transduction mechanisms, and pharmacologic properties. Group I includes GRM1 and GRM5 and these receptors have been shown to activate phospholipase C. Group II includes GRM2 and GRM3 while Group III includes GRM4, GRM6, GRM7 and GRM8. Group II and III receptors are linked to the inhibition of the cyclic AMP cascade but differ in their agonist selectivities. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Function	G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. May mediate suppression of neurotransmission or may be involved in synaptogenesis or synaptic stabilization. [UniProt]
Cellular Localization	Cell membrane; Multi-pass membrane protein. Cell junction, synapse. Cell projection, dendrite. [UniProt]
Calculated MW	96 kDa

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