ARG22244
anti-mGluR1 + mGluR5 antibody [S75-33]
anti-mGluR1 + mGluR5 antibody [S75-33] for Immunohistochemistry,Immunoprecipitation,Western blot and Human,Mouse,Rat
Overview
| Product Description | Mouse Monoclonal antibody [S75-33] recognizes mGluR1 + mGluR5 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | IHC, IP, WB |
| Specificity | Detects ~130kDa (both mGluR1 and mGluR5). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | S75-33 |
| Isotype | IgG1 |
| Target Name | mGluR1 + mGluR5 |
| Antigen Species | Rat |
| Immunogen | Fusion protein around aa. 824-1203 (cytoplasmic C-terminus) of Rat mGluR5b |
| Conjugation | Un-conjugated |
| Alternate Names | PPP1R86; mGlu5; GPRC1E; Metabotropic glutamate receptor 5; mGluR5; MGLUR5 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein G. |
| Buffer | PBS (pH 7.4), 0.09% Sodium azide and 50% Glycerol |
| Preservative | 0.09% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | Grm5 |
| Gene Full Name | glutamate receptor, metabotropic 5 |
| Background | This gene encodes a member of the G-protein coupled receptor 3 protein family. The encoded protein is a metabatropic glutamate receptor, whose signaling activates a phosphatidylinositol-calcium second messenger system. This protein may be involved in the regulation of neural network activity and synaptic plasticity. Glutamatergic neurotransmission is involved in most aspects of normal brain function and can be perturbed in many neuropathologic conditions. A pseudogene of this gene has been defined on chromosome 11. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2014] |
| Function | G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling activates a phosphatidylinositol-calcium second messenger system and generates a calcium-activated chloride current. Plays an important role in the regulation of synaptic plasticity and the modulation of the neural network activity. [UniProt] |
| Cellular Localization | Cell membrane |
| Calculated MW | ~130 kDa (both mGluR1 and mGluR5). |
Images (1) Click the Picture to Zoom In
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ARG22244 anti-mGluR1 + mGluR5 antibody [S75-33] WB image
Western blot: Rat brain membrane lysate stained with ARG22244 anti-mGluR1 + mGluR5 antibody [S75-33] at 1:1000 dilution.
