ARG56255
anti-hnRNP A2B1 antibody
anti-hnRNP A2B1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes hnRNP A2B1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | hnRNP A2B1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human hnRNP A2B1 |
| Conjugation | Un-conjugated |
| Alternate Names | SNRPB1; Heterogeneous nuclear ribonucleoproteins A2/B1; HNRNPB1; HNRNPA2; HNRPA2B1; RNPA2; HNRPB1; HNRPA2; IBMPFD2; hnRNP A2/B1 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | PC3 |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purification with immunogen. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | HNRNPA2B1 |
| Gene Full Name | heterogeneous nuclear ribonucleoprotein A2/B1 |
| Background | This gene belongs to the A/B subfamily of ubiquitously expressed heterogeneous nuclear ribonucleoproteins (hnRNPs). The hnRNPs are RNA binding proteins and they complex with heterogeneous nuclear RNA (hnRNA). These proteins are associated with pre-mRNAs in the nucleus and appear to influence pre-mRNA processing and other aspects of mRNA metabolism and transport. While all of the hnRNPs are present in the nucleus, some seem to shuttle between the nucleus and the cytoplasm. The hnRNP proteins have distinct nucleic acid binding properties. The protein encoded by this gene has two repeats of quasi-RRM domains that bind to RNAs. This gene has been described to generate two alternatively spliced transcript variants which encode different isoforms. [provided by RefSeq, Jul 2008] |
| Function | Involved with pre-mRNA processing. Forms complexes (ribonucleosomes) with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. [UniProt] |
| Calculated MW | 37 kDa |
| PTM | Sumoylated in exosomes, promoting miRNAs-binding. Asymmetric dimethylation at Arg-266 constitutes the major methylation site (By similarity). According to a report, methylation affects subcellular location and promotes nuclear localization (PubMed:10772824). According to another report, methylation at Arg-266 does not influence nucleocytoplasmic shuttling (By similarity). |
Images (3) Click the Picture to Zoom In
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ARG56255 anti-hnRNP A2B1 antibody ICC/IF image
Immunofluorescence: A549 cells stained with ARG56255 anti-hnRNP A2B1 antibody. Blue: DAPI for nuclear staining.
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ARG56255 anti-hnRNP A2B1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human kidney stained with ARG56255 anti-hnRNP A2B1 antibody at 1:200 dilution.
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ARG56255 anti-hnRNP A2B1 antibody WB image
Western blot: PC3 cell lysate stained with ARG56255 anti-hnRNP A2B1 antibody.
