ARG62676
anti-beta 2 Microglobulin antibody [B2M-01] (Biotin)
anti-beta 2 Microglobulin antibody [B2M-01] (Biotin) for Flow cytometry and Human
Cancer antibody; Cell Biology and Cellular Response antibody
Overview
| Product Description | Biotin-conjugated Mouse Monoclonal antibody [B2M-01] recognizes beta 2 Microglobulin |
|---|---|
| Tested Reactivity | Hu |
| Species Does Not React With | Ms, Bov, Chk, Dog, Rb |
| Tested Application | FACS |
| Specificity | The clone B2M-01 reacts with beta2-microglobulin (beta2M) associated with cell-surface MHC Class I molecules and other membrane antigens as well as with soluble beta2-microglobulin. Beta2M is a 12 kDa Ig like glycoprotein expressed on lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells and epithelial cells. It is absent on erythrocytes._x000D_ |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | B2M-01 |
| Isotype | IgG2a |
| Target Name | beta 2 Microglobulin |
| Antigen Species | Human |
| Immunogen | Purified human beta2-microglobulin |
| Conjugation | Biotin |
| Alternate Names | Beta-2-microglobulin |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification Note | The purified antibody is conjugated with Biotin-LC-NHS under optimum conditions. The reagent is free of unconjugated biotin. |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | Aliquot and store in the dark at 2-8°C. Keep protected from prolonged exposure to light. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | B2M |
| Gene Full Name | beta-2-microglobulin |
| Background | Beta2-microglobulin non-covalently associates with the 44 kDa alpha chain to forms the HLA Class I antigen complex. Human beta2-microglobulin associated with HLA Class I antigens is expressed on many types of cells including lymphocytes, thymocytes, monocytes, granulocytes, platelets, endothelial cells, and epithelial cells. It is absent on erythrocytes. |
| Function | Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system. [UniProt] |
| Research Area | Cancer antibody; Cell Biology and Cellular Response antibody |
| Calculated MW | 14 kDa |
| PTM | Glycation of Ile-21 is observed in long-term hemodialysis patients. |
Images (1) Click the Picture to Zoom In
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ARG62676 anti-beta 2 Microglobulin antibody [B2M-01] (Biotin) FACS image
Flow Cytometry: Human peripheral blood stained with ARG62676 anti-beta 2 Microglobulin antibody [B2M-01] (Biotin), followed by Streptavidin (APC).
Clone References
Divalent cations regulate the folding and activation status of integrins during their intracellular trafficking.
FcRn binding properties of an abnormal truncated analbuminemic albumin variant.
ELISA / Human
Cell characterization by proteome profiling applied to primary hepatocytes and hepatocyte cell lines Hep-G2 and Hep-3B.
WB / Human
Oncostatin M enhances the antiviral effects of type I interferon and activates immunostimulatory functions in liver epithelial cells.
WB / Human
Beta2-microglobulin as a biomarker in peripheral arterial disease: proteomic profiling and clinical studies.
Comparison of biological activity among nonfucosylated therapeutic IgG1 antibodies with three different N-linked Fc oligosaccharides: the high-mannose, hybrid, and complex types.
