ARG41030
anti-YEATS4 / GAS41 antibody
anti-YEATS4 / GAS41 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Overview
| Product Description | Rabbit Polyclonal antibody recognizes YEATS4 / GAS41 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | YEATS4 / GAS41 |
| Antigen Species | Human |
| Immunogen | Recombinant fusion protein corresponding to aa. 1-227 of Human YEATS4 (NP_006521.1). |
| Conjugation | Un-conjugated |
| Alternate Names | NUBI-1; NuMA-binding protein 1; NuBI1; YEATS domain-containing protein 4; B230215M10Rik; Glioma-amplified sequence 41; YAF9; NuBI-1; Gas41; 4930573H17Rik; GAS41 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Positive Control | U-251MG | ||||||||
| Observed Size | 26 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified. |
| Buffer | PBS (pH 7.3), 0.02% Sodium azide and 50% Glycerol. |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 50% Glycerol |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | YEATS4 |
| Gene Full Name | YEATS domain containing 4 |
| Background | The protein encoded by this gene is found in the nucleoli. It has high sequence homology to human MLLT1, and yeast and human MLLT3 proteins. Both MLLT1 and MLLT3 proteins belong to a class of transcription factors, indicating that the encoded protein might also represent a transcription factor. This protein is thought to be required for RNA transcription. This gene has been shown to be amplified in tumors. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Jul 2014] |
| Function | Component of the NuA4 histone acetyltransferase (HAT) complex which is involved in transcriptional activation of select genes principally by acetylation of nucleosomal histones H4 and H2A. This modification may both alter nucleosome - DNA interactions and promote interaction of the modified histones with other proteins which positively regulate transcription. This complex may be required for the activation of transcriptional programs associated with oncogene and proto-oncogene mediated growth induction, tumor suppressor mediated growth arrest and replicative senescence, apoptosis, and DNA repair. NuA4 may also play a direct role in DNA repair when recruited to sites of DNA damage. [UniProt] |
| Cellular Localization | Nucleus. [UniProt] |
| Calculated MW | 26 kDa |
Images (1) Click the Picture to Zoom In
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ARG41030 anti-YEATS4 / GAS41 antibody WB image
Western blot: 25 µg of U-251MG cell lysate stained with ARG41030 anti-YEATS4 / GAS41 antibody at 1:1000 dilution.
