ARG45491
anti-WFS1 antibody
anti-WFS1 antibody for Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Monkey
Overview
| Product Description | Rabbit Polyclonal antibody recognizes WFS1 |
|---|---|
| Tested Reactivity | Hu, Mk |
| Tested Application | FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | WFS1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein containing to human WFS1. |
| Conjugation | Un-conjugated |
| Alternate Names | WFS1; Wolframin ER Transmembrane Glycoprotein; WFS; Wolfram Syndrome 1 (Wolframin); Wolframin; DIDMOAD; CTRCT41; DFNA14; DFNA38; DFNA6; WFRS; WFSL |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||||
| Observed Size | 100 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.2% Na2HPO4, 0.9% NaCl and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | WFS1 |
| Gene Full Name | Wolframin ER Transmembrane Glycoprotein |
| Background | This gene encodes a transmembrane protein, which is located primarily in the endoplasmic reticulum and ubiquitously expressed with highest levels in brain, pancreas, heart, and insulinoma beta-cell lines. Mutations in this gene are associated with Wolfram syndrome, also called DIDMOAD (Diabetes Insipidus, Diabetes Mellitus, Optic Atrophy, and Deafness), an autosomal recessive disorder. The disease affects the brain and central nervous system. Mutations in this gene can also cause autosomal dominant deafness 6 (DFNA6), also known as DFNA14 or DFNA38. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2009] |
| Function | Participates in the regulation of cellular Ca2+ homeostasis, at least partly, by modulating the filling state of the endoplasmic reticulum Ca2+ store. [UniProt] |
| Cellular Localization | Cytoplasmic vesicle; Endoplasmic reticulum; Membrane. [UniProt] |
| Calculated MW | 100 kDa |
| PTM | Acetylation; Glycoprotein; Phosphoprotein. [UniProt] |
Images (5) Click the Picture to Zoom In
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ARG45491 anti-WFS1 antibody IHC-P image
Immunohistochemistry: Human lung cancer stained with ARG45491 anti-WFS1 antibody at 2 μg/ml dilution.
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ARG45491 anti-WFS1 antibody ICC/IF image
Immunofluorescence: HepG2 stained with ARG45491 anti-WFS1 antibody at 5 μg/ml dilution.
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ARG45491 anti-WFS1 antibody WB image
Western blot: T-47D stained with ARG45491 anti-WFS1 antibody at 0.5 μg/ml dilution.
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ARG45491 anti-WFS1 antibody FACS image
Flow Cytometry: U20S stained with ARG45491 anti-WFS1 antibody at 1 µg/10^6 cells dilution.
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ARG45491 anti-WFS1 antibody WB image
Western blot: Monkey lung stained with ARG45491 anti-WFS1 antibody at 0.5 μg/ml dilution.
