ARG44010
anti-VDAC1 / Porin antibody
anti-VDAC1 / Porin antibody for ELISA,Flow cytometry,ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse,Rat
Controls and Markers antibody; Metabolism antibody; Signaling Transduction antibody
Overview
| Product Description | Rabbit Polyclonal antibody recognizes VDAC1 |
|---|---|
| Tested Reactivity | Hu, Ms, Rat |
| Tested Application | ELISA, FACS, ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Target Name | VDAC1 |
| Antigen Species | Human |
| Immunogen | Human VDAC1 recombinant protein |
| Expression System | E.coli |
| Conjugation | Un-conjugated |
| Protein Full Name | Voltage-dependent anion-selective channel protein 1 |
| Alternate Names | VDAC1; Voltage Dependent Anion Channel 1; PORIN; Voltage-Dependent Anion-Selective Channel Protein 1; Outer Mitochondrial Membrane Protein Porin 1; Plasmalemmal Porin; Porin 31HL; Porin 31HM; MGC111064; VDAC-1; Sperm Binding Protein 1a; HVDAC1; VDAC |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Buffer | 0.9% NaCl, 0.2% Na2HPO4 and 4% Trehalose. |
| Stabilizer | 4% Trehalose |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | VDAC1 |
| Gene Full Name | voltage-dependent anion channel 1 |
| Background | This gene encodes a voltage-dependent anion channel protein that is a major component of the outer mitochondrial membrane. The encoded protein facilitates the exchange of metabolites and ions across the outer mitochondrial membrane and may regulate mitochondrial functions. This protein also forms channels in the plasma membrane and may be involved in transmembrane electron transport. Alternate splicing results in multiple transcript variants. Multiple pseudogenes of this gene are found on chromosomes 1, 2 3, 6, 9, 12, X and Y.[provided by RefSeq, Sep 2010] |
| Function | Forms a channel through the mitochondrial outer membrane and also the plasma membrane. The channel at the outer mitochondrial membrane allows diffusion of small hydrophilic molecules; in the plasma membrane it is involved in cell volume regulation and apoptosis. It adopts an open conformation at low or zero membrane potential and a closed conformation at potentials above 30-40 mV. The open state has a weak anion selectivity whereas the closed state is cation-selective. [UniProt] |
| Cellular Localization | Cell membrane, Membrane, Mitochondrion, Mitochondrion outer membrane. [UniProt] |
| Research Area | Controls and Markers antibody; Metabolism antibody; Signaling Transduction antibody |
| Calculated MW | 31 kDa |
| PTM | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation. [UniProt] |
Images (6) Click the Picture to Zoom In
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ARG44010 anti-VDAC1 / Porin antibody IHC-P image
Immunohistochemistry: Human colorectal adenocarcinoma stained with ARG44010 anti-VDAC1 / Porin antibody at 2 μg/ml dilution.
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ARG44010 anti-VDAC1 / Porin antibody WB image
Western blot: A431 and 293T stained with ARG44010 anti-VDAC1 / Porin antibody at 0.5 μg/mL dilution.
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ARG44010 anti-VDAC1 / Porin antibody ICC/IF image
Immunofluorescence: HELA cells stained with ARG44010 anti-VDAC1 / Porin antibody at 5 μg/ml dilution.
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ARG44010 anti-VDAC1 / Porin antibody IHC-P image
Immunohistochemistry: Human liver cancer stained with ARG44010 anti-VDAC1 / Porin antibody at 2 μg/ml dilution.
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ARG44010 anti-VDAC1 / Porin antibody WB image
Western blot: Rat heart and Rat liver stained with ARG44010 anti-VDAC1 / Porin antibody at 0.5 μg/mL dilution.
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ARG44010 anti-VDAC1 / Porin antibody WB image
Western blot: Mouse heart and Mouse liver stained with ARG44010 anti-VDAC1 / Porin antibody at 0.5 μg/mL dilution.
