Overview

Product Description	Mouse Monoclonal antibody recognizes UBR1
Tested Reactivity	Hu
Tested Application	WB
Host	Mouse
Clonality	Monoclonal
Isotype	IgG
Target Name	UBR1
Antigen Species	Human
Conjugation	Un-conjugated
Alternate Names	UBR1; Ubiquitin Protein Ligase E3 Component N-Recognin1; Ubiquitin-Protein Ligase E3-Alpha-1; Ubiquitin-Protein Ligase E3-Alpha-I; E3 Ubiquitin-Protein Ligase UBR1; N-Recognin-1; RING-Type E3 Ubiquitin Transferase UBR1; Ubiquitin-Protein Ligase E3-Alpha; Ubiquitin Ligase E3 Alpha-I; EC2.3.2.27; E3a Ligase; JBS

Application Instructions

Application Suggestion	Tested Application Dilution WB 1:2000
Application Note	* The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.

Properties

Form	Liquid
Purification	Protein A purification
Buffer	PBS with0.09% sodium azide
Preservative	0.09% sodium azide
Storage Instruction	For continuous use, store undiluted antibody at2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note	For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links	GeneID: 197131 Human UBR1 Swiss-port # Q8IWV7 Human E3 ubiquitin-protein ligase UBR1
Gene Symbol	UBR1
Gene Full Name	Ubiquitin Protein Ligase E3 Component N-Recognin1
Background	The N-end rule pathway is one proteolytic pathway of the ubiquitin system. The recognition component of this pathway, encoded by this gene, binds to a destabilizing N-terminal residue of a substrate protein and participates in the formation of a substrate-linked multiubiquitin chain. This leads to the eventual degradation of the substrate protein. The protein described in this record has a RING-type zinc finger and a UBR-type zinc finger. Mutations in this gene have been associated with Johanson-Blizzard syndrome. [provided by RefSeq, Jul2008]
Function	Binds leucine and is a negative regulator of the leucine-mTOR signaling pathway, thereby controlling cell growth. [Uniprot]
Cellular Localization	Cytoplasm. [Uniprot]
PTM	Acetylation, Phosphoprotein. [Uniprot]

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