ARG63113
anti-Thyroglobulin antibody [TSH-116]
anti-Thyroglobulin antibody [TSH-116] for ELISA,Radioimmunoassay and Human
Cancer antibody; Signaling Transduction antibody
Overview
| Product Description | Mouse Monoclonal antibody [TSH-116] recognizes Thyroglobulin |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ELISA, RIA |
| Specificity | The clone TSH-116 reacts with human thyroid stimulating hormone (hTSH, thyrotropin), a glycoprotein hormone produced by the anterior pituitary gland cells in response to signals from the hypothalamus gland in the brain. The TSH-116 reacts with association constant 1.1 x 1011 l/mol. Following cross-reactivity expressed as binding of labelled hormone (% of total) was determined by solid phase RIA with excess of the antibody TSH-116: hTSH (78.9), hCG (20.3), hLH (23.2), hFSH (29.9). |
| Host | Mouse |
| Clonality | Monoclonal |
| Clone | TSH-116 |
| Isotype | IgG2a |
| Target Name | Thyroglobulin |
| Antigen Species | Human |
| Immunogen | Human thyrotropin. |
| Conjugation | Un-conjugated |
| Alternate Names | AITD3; Tg; TGN; Thyroglobulin |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|---|---|
| Application Note | RIA: The clone TSH-116 is suitable in combination with the clone TSH-51 (ARG63112) for immunometric assays in the screening of neonatal hypothyroidism. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from ascites by protein-A affinity chromatography. |
| Purity | > 95% (by SDS-PAGE) |
| Buffer | PBS (pH 7.4) and 15 mM Sodium azide |
| Preservative | 15 mM Sodium azide |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TG |
| Gene Full Name | thyroglobulin |
| Background | Thyrotropin (hTSH) promotes the growth of the thyroid gland in the neck and stimulates it to produce more thyroid hormones. hTSH is composed of two subunits - alpha nad beta. |
| Function | Precursor of the iodinated thyroid hormones thyroxine (T4) and triiodothyronine (T3). [UniProt] |
| Research Area | Cancer antibody; Signaling Transduction antibody |
| Calculated MW | 305 kDa |
| PTM | Sulfated tyrosines are desulfated during iodination. |
