ARG64424
anti-TUSC4 / NPRL2 antibody
anti-TUSC4 / NPRL2 antibody for Western blot and Human
Cancer antibody; Gene Regulation antibody
Overview
| Product Description | Goat Polyclonal antibody recognizes TUSC4 / NPRL2 |
|---|---|
| Tested Reactivity | Hu |
| Predict Reactivity | Ms |
| Tested Application | WB |
| Host | Goat |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TUSC4 / NPRL2 |
| Antigen Species | Human |
| Immunogen | QYSNVYCPTPKV |
| Conjugation | Un-conjugated |
| Alternate Names | TUSC4; Gene 21 protein; NPR2; NPR2-like protein; Tumor suppressor candidate 4; Nitrogen permease regulator 2-like protein; G21 protein; NPR2L |
Application Instructions
| Application Suggestion |
|
||||
|---|---|---|---|---|---|
| Application Note | WB: Recommend incubate at RT for 1h. * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
| Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
| Preservative | 0.02% Sodium azide |
| Stabilizer | 0.5% BSA |
| Concentration | 0.5 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8WTW4 Human Nitrogen permease regulator 2-like protein |
|---|---|
| Gene Symbol | NPRL2 |
| Gene Full Name | nitrogen permease regulator-like 2 (S. cerevisiae) |
| Function | Suppresses Src-dependent tyrosine phosphorylation and activation of PDPK1 and its downstream signaling. Down-regulates PDPK1 kinase activity by interfering with tyrosine phosphorylation at 'Tyr-9', 'Tyr-373' and 'Tyr-376' residues. May act as a tumor suppressor. Suppresses cell growth and enhances sensitivity to various anticancer drugs. As a component of the GATOR1 complex, inhibitor of the amino acid-sensing branch of the TORC1 pathway. The GATOR1 complex strongly increases GTP hydrolysis by RRAGA and RRAGB within RRAGC-containing heterodimers, thereby deactivating RRAGs, releasing mTORC1 from lysosomal surface and inhibiting mTORC1 signaling. [UniProt] |
| Research Area | Cancer antibody; Gene Regulation antibody |
| Calculated MW | 44 kDa |
Images (1) Click the Picture to Zoom In
-
ARG64424 anti-TUSC4 / NPRL2 antibody WB image
Western Blot: Human Muscle lysate (35 µg protein in RIPA buffer) stained with ARG64424 anti-TUSC4 / NPRL2 (aa 140 to 151) antibody at 0.1 µg/ml dilution.
