ARG67048
anti-TRPS1 antibody [SQab30333]
anti-TRPS1 antibody [SQab30333] for IHC-Formalin-fixed paraffin-embedded sections and Human
Overview
| Product Description | Recombinant rabbit Monoclonal antibody [SQab30333] recognizes TRPS1 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | IHC-P |
| Host | Rabbit |
| Clonality | Monoclonal |
| Clone | SQab30333 |
| Isotype | IgG |
| Target Name | TRPS1 |
| Antigen Species | Human |
| Immunogen | Recombinant protein of Human TRPS1 |
| Conjugation | Un-conjugated |
| Protein Full Name | Zinc finger transcription factor Trps1 |
| Alternate Names | TRPS1, Transcriptional Repressor GATA Binding 1, LGCR, GC79, Tricho-Rhino-Phalangeal Syndrome Type I Protein, Zinc Finger Transcription Factor Trps1, Trichorhinophalangeal Syndrome I, Zinc Finger Protein GC79 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Positive Control | Beast cancer |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS, 0.01% Sodium azide, 40% Glycerol and 0.05%BSA. |
| Preservative | 0.01% Sodium azide |
| Stabilizer | 40% Glycerol and 0.05%BSA |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q9UHF7 Human Zinc finger transcription factor Trps1 |
|---|---|
| Gene Symbol | TRPS1 |
| Gene Full Name | Transcriptional Repressor GATA Binding 1 |
| Background | This gene encodes a transcription factor that represses GATA-regulated genes and binds to a dynein light chain protein. Binding of the encoded protein to the dynein light chain protein affects binding to GATA consensus sequences and suppresses its transcriptional activity. Defects in this gene are a cause of tricho-rhino-phalangeal syndrome (TRPS) types I-III. [provided by RefSeq, Jul 2008] |
| Function | Transcriptional repressor. Binds specifically to GATA sequences and represses expression of GATA-regulated genes at selected sites and stages in vertebrate development. Regulates chondrocyte proliferation and differentiation. Executes multiple functions in proliferating chondrocytes, expanding the region of distal chondrocytes, activating proliferation in columnar cells and supporting the differentiation of columnar into hypertrophic chondrocytes. [UniProt] |
| Cellular Localization | Nucleus |
| Calculated MW | 141 kDa |
| PTM | Sumoylated. Sumoylation in the repressor domain inhibits the transcription repression activity. Sumoylation on Lys-1201 is the major site. Appears to be sumoylated on multiple sites. [UniProt] |
Images (1) Click the Picture to Zoom In
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ARG67048 anti-TRPS1 antibody [SQab30333] IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded breast cancer stained with ARG67048 anti-TRPS1 antibody [SQab30333].
