ARG41134
anti-TGM2 / Tissue transglutaminase antibody
anti-TGM2 / Tissue transglutaminase antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TGM2 / Tissue transglutaminase |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TGM2 / Tissue transglutaminase |
| Antigen Species | Human |
| Immunogen | KLH-conjugated synthetic peptide corresponding to aa. 429-458 of Human TGM2 / Tissue transglutaminase. |
| Conjugation | Un-conjugated |
| Alternate Names | TG2; G-ALPHA-h; TGase H; Transglutaminase C; TGase C; HEL-S-45; Transglutaminase-2; Tissue transglutaminase; C; TGase-2; TGC; Protein-glutamine gamma-glutamyltransferase 2; TG; Transglutaminase H; GNAH; EC 2.3.2.13 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A. |
| Buffer | PBS and 0.09% (W/V) Sodium azide. |
| Preservative | 0.09% (W/V) Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P21980 Human Protein-glutamine gamma-glutamyltransferase 2 |
|---|---|
| Gene Symbol | TGM2 |
| Gene Full Name | transglutaminase 2 |
| Background | Transglutaminases are enzymes that catalyze the crosslinking of proteins by epsilon-gamma glutamyl lysine isopeptide bonds. While the primary structure of transglutaminases is not conserved, they all have the same amino acid sequence at their active sites and their activity is calcium-dependent. The protein encoded by this gene acts as a monomer, is induced by retinoic acid, and appears to be involved in apoptosis. Finally, the encoded protein is the autoantigen implicated in celiac disease. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008] |
| Function | Catalyzes the cross-linking of proteins and the conjugation of polyamines to proteins. [UniProt] |
| Calculated MW | 77 kDa |
Images (3) Click the Picture to Zoom In
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ARG41134 anti-TGM2 / Tissue transglutaminase antibody ICC/IF image
Immunofluorescence: U251 cells were fixed with 4% PFA (20 min), permeabilized with Triton X-100 (0.1%, 10 min), then stained with ARG41134 anti-TGM2 / Tissue transglutaminase antibody (green) at 1:25, 1 hour at 37°C. Cytoplasmic actin was counterstained with Alexa Fluor® 555 (red) conjugated Phalloidin (7 units/ml, 1 hour at 37°C). DAPI (blue) for nuclear staining.
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ARG41134 anti-TGM2 / Tissue transglutaminase antibody IHC-P image
Immunohistochemistry: Formalin-fixed and paraffin-embedded Human lung carcinoma tissue stained with ARG41134 anti-TGM2 / Tissue transglutaminase antibody.
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ARG41134 anti-TGM2 / Tissue transglutaminase antibody WB image
Western blot: 35 µg of HUVEC cell lysate stained with ARG41134 anti-TGM2 / Tissue transglutaminase antibody.
