ARG65030
anti-TET2 antibody
anti-TET2 antibody for IHC-Formalin-fixed paraffin-embedded sections and Human
Gene Regulation antibody
Overview
Product Description | Goat Polyclonal antibody recognizes TET2 |
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Tested Reactivity | Hu |
Predict Reactivity | Ms, Dog |
Tested Application | IHC-P |
Specificity | This antibody is expected to recognize both reported isoforms (NP_001120680.1; NP_060098.3). |
Host | Goat |
Clonality | Polyclonal |
Isotype | IgG |
Target Name | TET2 |
Antigen Species | Human |
Immunogen | C-PHPQSNNDQQREGSF |
Conjugation | Un-conjugated |
Alternate Names | MDS; KIAA1546; EC 1.14.11.n2; Methylcytosine dioxygenase TET2 |
Application Instructions
Application Suggestion |
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Application Note | IHC-P: Antigen Retrieval: Steam tissue section in Citrate buffer (pH 6.0). * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
Form | Liquid |
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Purification | Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide. |
Buffer | Tris saline (pH 7.3), 0.02% Sodium azide and 0.5% BSA |
Preservative | 0.02% Sodium azide |
Stabilizer | 0.5% BSA |
Concentration | 0.5 mg/ml |
Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
Database Links | |
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Background | The protein encoded by this gene is a methylcytosine dioxygenase that catalyzes the conversion of methylcytosine to 5-hydroxymethylcytosine. The encoded protein is involved in myelopoiesis, and defects in this gene have been associated with several myeloproliferative disorders. Two variants encoding different isoforms have been found for this gene. [provided by RefSeq, Mar 2011] |
Research Area | Gene Regulation antibody |
Calculated MW | 224 kDa |
PTM | May be glycosylated. It is unclear whether interaction with OGT leads to GlcNAcylation. According to a report, it is not GlcNAcylated by OGT (PubMed:23353889). In contrast, another group reports GlcNAcylation by OGT in mouse ortholog. |
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