ARG43640

anti-TERF2IP / RAP1 antibody

anti-TERF2IP / RAP1 antibody for Flow cytometry,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human

Controls and Markers antibody; Gene Regulation antibody

Overview

Product Description Mouse Monoclonal antibody recognizes TERF2IP / RAP1
Tested Reactivity Hu
Tested Application FACS, IHC-P, WB
Host Mouse
Clonality Monoclonal
Clone 1664CT564.52.88
Isotype IgG1, kappa
Target Name TERF2IP / RAP1
Antigen Species Human
Immunogen Recombinant protein corresponding to Human TERF2IP / RAP1.
Conjugation Un-conjugated
Protein Full Name Telomeric repeat-binding factor 2-interacting protein 1
Alternate Names Telomeric repeat-binding factor 2-interacting protein 1; TRF2-interacting telomeric protein 1; RAP1; DRIP5; RAP1 homolog; hRap1; Dopamine receptor-interacting protein 5; Repressor/activator protein 1 homolog; TERF2-interacting telomeric protein 1

Application Instructions

Application Suggestion
Tested Application Dilution
FACS1:10 - 1:25
IHC-P1:10 - 1:25
WB1:500 - 1:1000
Application Note * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist.
Observed Size ~60 kDa

Properties

Form Liquid
Purification Purification with Protein A and immunogen peptide.
Buffer PBS and 0.09% Sodium azide.
Preservative 0.09% Sodium azide
Storage Instruction For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use.
Note For laboratory research only, not for drug, diagnostic or other use.

Bioinformation

Database Links

GeneID: 54386 Human TERF2IP

Swiss-port # Q9NYB0 Human Telomeric repeat-binding factor 2-interacting protein 1

Gene Symbol TERF2IP
Gene Full Name telomeric repeat binding factor 2, interacting protein
Background The gene encodes a protein that is part of a complex involved in telomere length regulation. Pseudogenes are present on chromosomes 5 and 22. [provided by RefSeq, Apr 2010]
Function Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes. [UniProt]
Cellular Localization Nucleus. Cytoplasm. Chromosome. Chromosome, telomere. Note=Associates with chromosomes, both at telomeres and in extratelomeric sites. Also exists as a cytoplasmic form, where it associates with the IKK complex (By similarity).
Research Area Controls and Markers antibody; Gene Regulation antibody
Calculated MW 44 kDa
PTM Acetylation; Isopeptide bond; Phosphoprotein; Ubl conjugation