ARG44330
anti-TDP2 antibody
anti-TDP2 antibody for Western blot and Human
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TDP2 |
|---|---|
| Tested Reactivity | Hu |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TDP2 |
| Antigen Species | Human |
| Immunogen | Synthetic peptide |
| Conjugation | Un-conjugated |
| Alternate Names | TDP2; Tyrosyl-DNA Phosphodiesterase 2; TTRAP; TRAF And TNF Receptor-Associated Protein; 5'-Tyrosyl-DNA Phosphodiesterase; Tyrosyl-RNA Phosphodiesterase; 5'-Tyr-DNA Phosphodiesterase; Tyr-DNA Phosphodiesterase 2; ETS1-Associated Protein II; ETS1-Associated Protein 2; VPg Unlinkase; EAPII; HTDP2; EAP2; Epididymis Secretory Sperm Binding Protein; TRAF And TNF Receptor Associated Protein |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. |
Properties
| Form | Liquid |
|---|---|
| Purification | Antigen Affinity Purified |
| Buffer | PBS with 0.02% Sodium azide |
| Preservative | 0.02% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
Bioinformation
| Database Links | |
|---|---|
| Gene Symbol | TDP2 |
| Gene Full Name | Tyrosyl-DNA Phosphodiesterase 2 |
| Background | This gene encodes a member of a superfamily of divalent cation-dependent phosphodiesterases. The encoded protein associates with CD40, tumor necrosis factor (TNF) receptor-75 and TNF receptor associated factors (TRAFs), and inhibits nuclear factor-kappa-B activation. This protein has sequence and structural similarities with APE1 endonuclease, which is involved in both DNA repair and the activation of transcription factors. |
| Function | DNA repair enzyme that can remove a variety of covalent adducts from DNA through hydrolysis of a 5'-phosphodiester bond, giving rise to DNA with a free 5' phosphate. Catalyzes the hydrolysis of dead-end complexes between DNA and the topoisomerase 2 (TOP2) active site tyrosine residue. The 5'-tyrosyl DNA phosphodiesterase activity can enable the repair of TOP2-induced DNA double-strand breaks/DSBs without the need for nuclease activity, creating a 'clean' DSB with 5'-phosphate termini that are ready for ligation. |
| Cellular Localization | Cytoplasm, Nucleus |
| Calculated MW | 41 kDa |
| PTM | Acetylation, Isopeptide bond, Phosphoprotein, Ubl conjugation |
