ARG54030
anti-TBLR1 antibody
anti-TBLR1 antibody for ICC/IF,IHC-Formalin-fixed paraffin-embedded sections,Western blot and Human,Mouse
Cancer antibody; Gene Regulation antibody; Metabolism antibody
Overview
| Product Description | Mouse Monoclonal antibody recognizes TBL1XR1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | ICC/IF, IHC-P, WB |
| Host | Mouse |
| Clonality | Monoclonal |
| Isotype | IgG1 |
| Target Name | TBLR1 |
| Antigen Species | Human |
| Immunogen | Purified recombinant human TBLR1 protein fragments expressed in E.coli. |
| Conjugation | Un-conjugated |
| Alternate Names | C21; TBLR1; Nuclear receptor corepressor/HDAC3 complex subunit TBLR1; F-box-like/WD repeat-containing protein TBL1XR1; Transducin beta-like 1X-related protein 1; TBL1-related protein 1; IRA1; DC42 |
Application Instructions
| Application Suggestion |
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| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||||||
| Observed Size | 60 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Affinity purified |
| Buffer | 0.1M Tris-Glycine (pH 7.4), 150 mM NaCl, 0.2% Sodium azide and 50% Glycerol |
| Preservative | 0.2% Sodium azide |
| Stabilizer | 50% Glycerol |
| Concentration | 1 mg/ml |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # Q8BHJ5 Mouse F-box-like/WD repeat-containing protein TBL1XR1 Swiss-port # Q9BZK7 Human F-box-like/WD repeat-containing protein TBL1XR1 |
|---|---|
| Gene Symbol | TBL1XR1 |
| Gene Full Name | transducin (beta)-like 1 X-linked receptor 1 |
| Background | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, th ereby allowing cofactor exchange, and transcription activation. |
| Function | F-box-like protein involved in the recruitment of the ubiquitin/19S proteasome complex to nuclear receptor-regulated transcription units. Plays an essential role in transcription activation mediated by nuclear receptors. Probably acts as integral component of the N-Cor corepressor complex that mediates the recruitment of the 19S proteasome complex, leading to the subsequent proteasomal degradation of N-Cor complex, thereby allowing cofactor exchange, and transcription activation. [UniProt] |
| Cellular Localization | Nucleus |
| Research Area | Cancer antibody; Gene Regulation antibody; Metabolism antibody |
| Calculated MW | 56 kDa |
Images (3) Click the Picture to Zoom In
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ARG54030 anti-TBLR1 antibody ICC/IF image
Immunofluorescence: HeLa cells fixed with 4% Paraformaldehyde and stained with ARG54030 anti-TBLR1 antibody at 1:200 dilution.
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ARG54030 anti-TBLR1 antibody IHC-P image
Immunohistochemistry: Paraffin-embedded Human breast cancer tissue stained with ARG54030 anti-TBLR1 antibody at 1:500 - 1:1000 dilution.
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ARG54030 anti-TBLR1 antibody WB image
Western blot: K562 cell lysate stained with ARG54030 anti-TBLR1 antibody at 1:1000 dilution.
