ARG43638
anti-TAL1 antibody
anti-TAL1 antibody for Western blot and Human,Mouse
Overview
| Product Description | Rabbit Polyclonal antibody recognizes TAL1 |
|---|---|
| Tested Reactivity | Hu, Ms |
| Tested Application | WB |
| Host | Rabbit |
| Clonality | Polyclonal |
| Isotype | IgG |
| Target Name | TAL1 |
| Antigen Species | Mouse |
| Immunogen | Synthetic peptide within a.a 150-200 of Mouse TAL1 protein. |
| Conjugation | Un-conjugated |
| Protein Full Name | T-cell acute lymphocytic leukemia protein 1 |
| Alternate Names | tal-1; SCL; TCL5; bHLHa17; Class A basic helix-loop-helix protein 17; T-cell leukemia/lymphoma protein 5; Stem cell protein; T-cell acute lymphocytic leukemia protein 1; TAL-1 |
Application Instructions
| Application Suggestion |
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|---|---|---|---|---|---|
| Application Note | * The dilutions indicate recommended starting dilutions and the optimal dilutions or concentrations should be determined by the scientist. | ||||
| Observed Size | 35-50 kDa |
Properties
| Form | Liquid |
|---|---|
| Purification | Purification with Protein A and immunogen peptide. |
| Buffer | PBS and 0.09% Sodium azide. |
| Preservative | 0.09% Sodium azide |
| Storage Instruction | For continuous use, store undiluted antibody at 2-8°C for up to a week. For long-term storage, aliquot and store at -20°C or below. Storage in frost free freezers is not recommended. Avoid repeated freeze/thaw cycles. Suggest spin the vial prior to opening. The antibody solution should be gently mixed before use. |
| Note | For laboratory research only, not for drug, diagnostic or other use. |
Bioinformation
| Database Links |
Swiss-port # P17542 Human T-cell acute lymphocytic leukemia protein 1 Swiss-port # P22091 Mouse T-cell acute lymphocytic leukemia protein 1 homolog |
|---|---|
| Gene Symbol | Tal1 |
| Gene Full Name | T cell acute lymphocytic leukemia 1 |
| Background | Enables several functions, including DNA-binding transcription factor activity; E-box binding activity; and histone deacetylase binding activity. Involved in several processes, including myeloid cell differentiation; positive regulation of cellular component organization; and positive regulation of erythrocyte differentiation. Located in chromatin and nucleoplasm. Part of transcription regulator complex. Implicated in acute lymphoblastic leukemia. [provided by Alliance of Genome Resources, Apr 2022] |
| Function | Implicated in the genesis of hemopoietic malignancies. It may play an important role in hemopoietic differentiation. Serves as a positive regulator of erythroid differentiation (By similarity). [UniProt] |
| Cellular Localization | Nucleus |
| Calculated MW | 34 kDa |
| PTM | Phosphorylated on serine residues. Phosphorylation of Ser-122 is strongly stimulated by hypoxia (By similarity). Ubiquitinated; subsequent to hypoxia-dependent phosphorylation of Ser-122, ubiquitination targets the protein for rapid degradation via the ubiquitin system. This process may be characteristic for microvascular endothelial cells, since it could not be observed in large vessel endothelial cells (By similarity). [UniProt] |
